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CAS No. : 191114-48-4
MCE 国际站:Telithromycin
产品活性:Telithromycin (HMR3647) 是一种结构类似大环内酯类的新型酮内酯类抗生素。Telithromycin 属于酮内酯家族,其特征是大环 3 位的酮群,对引起社区获得性肺炎、慢性支气管炎急性加重和急性鼻窦炎的细菌有活性。Telithromycin 也具有与大环内酯类相似的免疫调节作用。Telithromycin 可用于支气管哮喘等呼吸道感染的研究。
研究领域:Anti-infection
作用靶点:Bacterial | Antibiotic
In Vitro: Telithromycin (HMR3647) (0-50 μg/mL, 30 min) suppress C. pneumoniae-induced MUC5AC production.
Telithromycin (0-50 μg/mL, 30 min) suppress C. pneumoniae-induced NF-kB activation.
Telithromycin (10 mg/mL, 1 h) inhibits the production of MIP-2 and TNF-α in a dose-dependent manner by LPS-stimulated RAW 264.7 macrophages.
Telithromycin (10 mg/mL, 1 h) inhibits NF-kB activation, increases apoptosis in cell and decreases the LPS-induced influx of neutrophils in BAL fluid.
In Vivo: Telithromycin (HMR3647) (20 mg/kg, ip., single) reduces protein, nitrite, MIP-2, and TNF-α levels in the BAL fluid of LPS-nebulized animals.
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