MCE 的所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务。
CAS No. : 558640-51-0
MCE 国际站:VER-49009
产品活性:VER-49009 是一种 Hsp90 抑制剂,IC50 值为 25 nM,Kd 值为 78 nM。
研究领域:Cell Cycle/DNA Damage | Metabolic Enzyme/Protease
作用靶点:HSP
In Vitro: VER-49009 is a Hsp90 inhibitor, with an IC50 of 25 nM. VER-49009 binds to the ATPase of full length yeast Hsp90 protein, with an IC50 of 140 nM. VER-49009 inhibits Hsp90, with a Kd of 78 nM. VER-49009 also shows antiproliferative activities against various human cancer cells, with a mean GI50 of 685 ± 119 nM. VER-49009 suppressses the proliferation of human umbilical vein endothelial cells (HUVEC) with GI50 values of 444 ± 91.1 nM, and shows higher GI50s against nontumorigenic human breast (MCF10a) and prostate (PNT2) epithelial cells. VER-49009 displays no differences in cellular activities of isogenic cell lines, and these activities are independent of NQO1 expression. VER-49009 inhibits the proliferation (1, 2.5 μM), induces G2 phase arrest and reduces total Akt and phospho-Akt expression levels in CFSC cells (1-5 μM).
In Vivo: VER-49009 (4 mg/kg, i.p.) results in clear depletion of ERBB2 at 3 and 8 h following the final dose, with client protein levels returning to normal by 24 h, in the athymic mice bearing well-established OVCAR3 human ovarian ascites tumors.
相关产品:Bioactive Compound Library Plus | Cell Cycle/DNA Damage Compound Library | Metabolism/Protease Compound Library | Anti-Cancer Compound Library | Anti-Aging Compound Library | Endoplasmic Reticulum Stress Compound Library | Pyroptosis Compound Library | Cytoskeleton Compound Library | Anti-Prostate Cancer Compound Library | Membrane Protein-targeted Compound Library | Highly Selective Inhibitors Library | Hsp90-IN-17 | Palmitic acid | HSP90-IN-18 | Paeoniflorin | Pimitespib | Debio 0932 | HSP90-IN-22 | KU-177 | AMP-PCP disodium | Tamoxifen | JG-231 | MPC-0767 | HDAC6/HSP90-IN-1 | Retaspimycin | Onalespib | HM03 | EC144 | 2-Hexyl-4-pentynoic acid | Cucurbitacin D | Shepherdin (79-87) (TFA) | NCT-58 | MKT-077 | Cemdomespib | 6BrCaQ-C10-TPP | Rocaglamide | Novobiocin | Aminohexylgeldanamycin hydrochloride | Gedunin
热门产品线:重组蛋白 | 化合物库 | 天然产物 | 荧光染料 | PROTAC | 同位素标记物 | 寡核苷酸 | 抗体 | 点击化学
Trending products:Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Fluorescent Dye | PROTAC | Isotope-Labeled Compounds | Oligonucleotides | Antibodies | Click Chemistry
货号: HY-15986
品牌介绍:
• MCE (MedChemExpress) 拥有200 多种全球独家化合物库,我们致力于为全球科研客户提供前沿最全的高品质小分子活性化合物;
• 50,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领;
• 产品种类涵盖各种重组蛋白,多肽,常用试剂盒 ,更有 PROTAC、ADC 等特色产品,广泛应用于新药研发、生命科学等科研项目;
• 提供虚拟筛选,离子通道筛选,代谢组学分析检测分析,药物筛选等专业技术服务;
• 设有专业的实验中心和严格的质控、验证体系;
• 提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告,确保产品的高纯度、高品质;
• 产品的生物活性多经各国客户实验验证;
• Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果;
• 专业团队跟踪最新的制药及生命科学研究进展,为您提供全球最新的活性化合物;
• 与世界各大制药公司及知名科研机构建立了长期的合作。