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CAS No. : 10299-44-2
MCE 国际站:8-Azaadenosine
产品活性:8-Azaadenosine 是一种有效的 ADAR1 抑制剂。8-Azaadenosine 是一种 A-to-I 编辑抑制剂。8-Azaadenosine 可阻断 RNA 编辑并抑制甲状腺癌细胞的增殖、3D 生长、侵袭和迁移。
研究领域:Metabolic Enzyme/Protease
作用靶点:Adenosine Deaminase
In Vitro: 8-Azaadenosine targets ADAR (adenosine deaminases acting on double-stranded RNA) activity only and does not affect ADAR1 mRNA levels.
8-Azaadenosine (10-25 nM) restores let-7 miRNA biogenesis commensurate with a reduction in ADAR1 expression, RNA editing activity and LIN28B expression in JAK2/BCR-ABL1 transduced progenitors after two weeks in stromal co-culture.
8-Azaadenosine (10, 100 nM) shows no effect on BCR-ABL and JAK2 signaling, as demonstrated by qRT-PCR analysis and p-CRKL and p-STAT5a Western blot analysis.
8-Azaadenosine (0.1, 0.5, 1, 2 µM; 5 days) decreases cell viability/proliferation in a dose-dependent manner in TPC1 and Cal62 cells.
8-Azaadenosine (1, 2 µM; 16 hours) impedes invasion and migration of TPC1 and Cal62 cells.
8-Azaadenosine (1, 2 µM) inhibits the editing activity in TPC1 and Cal62 cells. By contrast, ADAR1 mRNA levels remains stable in both cells lines.
相关产品:Bioactive Compound Library Plus | Immunology/Inflammation Compound Library | Metabolism/Protease Compound Library | Anti-Cancer Compound Library | Targeted Diversity Library | Heterocyclic Compound Library | Membrane Protein-targeted Compound Library | AMPD2 inhibitor 2 | EHNA hydrochloride | Adenosine deaminase (RnADA) | Cladribine | Hibifolin | AMPD2 inhibitor 1 | Coformycin | 1-Deazaadenosine | Pentostatin | L-Adenosine
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