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AZD8848

CAS No. : 866269-28-5

MCE 国际站：AZD8848

产品活性：AZD8848 是一种选择性的 TLR7 前体药激动剂，用于哮喘和过敏性鼻炎的研究。

研究领域：Immunology/Inflammation

作用靶点：Toll-like Receptor (TLR)

In Vitro: AZD8848 shows good activity against TLR7, with cellular pEC₅₀s of 7.0 and 6.6 for human TLR7 and rat TLR7, respectively.
AZD8848 has an EC₅₀ of 4 nM in the induction of IFNα from human PBMCs and an IC₅₀ of 0.2-1.0 nM for the inhibition of IL-5, irrespective of whether the T cells have been polyclonally stimulated with PHA or via antigen presentation.
AZD8848 is a potent, selective TLR7 agonist antedrug able to inhibit Th2 responses in vitro.
AZD8848 has no activity against human TLR8 or against any of the other human TLRs.

In Vivo: AZD8848 (0.1-1 mg/kg; intratracheal) has a good pharmacokinetics in the Brown Norway rat.
AZD8848 (0.3 mg/kg; Intratracheal) suppresses the ovalbumin (OVA) challenge in the rat allergy model.

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