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CAS No. : 2245697-86-1
MCE 国际站:Thalidomide-O-amido-C4-NH2 hydrochloride
产品活性:Thalidomide-O-amido-C4-NH2 hydrochloride 是一种合成的 E3 连接酶配体-linker 偶联物,包含基于 Thalidomide 的 cereblon 配体和 1 个 linker。可用于合成 PROTAC 分子。
研究领域:PROTAC
作用靶点:E3 Ligase Ligand-Linker Conjugates
In Vitro: Thalidomide-O-amido-C4-NH2 is an amine intermediate (Compound 41), which can be used as is a heterobifunctional PROTAC BET degrader. The bromodomain and extra-terminal (BET) family proteins, consisting of BRD2, BRD3, BRD4, and testis-specific BRDT members, are epigenetic “readers” and play a key role in the regulation of gene transcription. BET proteins are considered to be attractive therapeutic targets for cancer and other human diseases. Recently, heterobifunctional small-molecule BET degraders have been designed based upon the proteolysis targeting chimera (PROTAC) concept to induce BET protein degradation. Thalidomide-O-amido-C4-NH2 is a degron-linker (refer to Compound DL6-TL). Degron-linker-targeting ligand, wherein the linker is covalently bound lo at least one degron and at least one targeting ligand, the degron is a compound capable of binding to an ubiquitin ligase such as an E3 ubiquitin ligase (e g, cereblon), and the targeting ligand is capable of binding to the targeted protein (s).
相关产品:Pomalidomide-C4-NH2 hydrochloride | Thalidomide-O-amido-PEG2-C2-NH2 hydrochloride | Pomalidomide-amino-PEG5-NH2 | Thalidomide-NH-C6-NH2 | Thalidomide-NH-amido-C6-NH2 hydrochloride | Thalidomide-Piperazine-PEG1-NH2 diTFA | Thalidomide-amido-PEG2-NH2 | Thalidomide-NH-C4-NH2 TFA | Thalidomide-NH-amido-C8-NH2 | Pomalidomide-PEG2-azide | 2-(2,6-Dioxopiperidin-3-yl)phthalimidine-C5-Br | Thalidomide-NH-amido-PEG3-C2-NH2 | Pomalidomide 4'-alkylC5-acid | Thalidomide-O-amido-PEG2-C2-NH2 TFA | Pomalidomide 4'-PEG5-acid | Thalidomide-NH-PEG4-Ms | Pomalidomide-C2-amido-(C1-O-C5-O-C1)2-COOH | cIAP1 Ligand-Linker Conjugates 2 Hydrochloride | (S,R,S)-AHPC-PEG3-propionic acid | N-Boc-SBP-0636457-O-C3-COOH | Pomalidomide-PEG1-C2-COOH | Thalidomide-Piperazine-PEG3-COOH | Thalidomide-Piperazine-PEG2-NH2 diTFA | (S,R,S)-AHPC-C4-NH2 | (S,R,S)-AHPC-PEG3-N3 | Thalidomide-O-C5-NH2 hydrochloride | Thalidomide-Propargyne-PEG2-COOH | Thalidomide-O-amido-PEG-C2-NH2 hydrochloride | Lenalidomide-C5-NH2 hydrochloride | (S,R,S)-AHPC-amido-C7-acid
热门产品线:重组蛋白 | 化合物库 | 天然产物 | 荧光染料 | PROTAC | 同位素标记物 | 寡核苷酸 | 抗体 | 点击化学
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货号: HY-107438A
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