MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

GNE-617 hydrochloride

CAS No. : 2070014-99-0

MCE 国际站：GNE-617 hydrochloride

产品活性：GNE-617 hydrochloride 是一种特异性的 NAMPT 抑制剂，抑制 NAMPT 活性，IC₅₀ 为 5 nM。

研究领域：Metabolic Enzyme/Protease

作用靶点：NAMPT

In Vitro: The activity ofGNE-617 hydrochloride is evaluated on a panel 53 non-small cell lung cancer (NSCLC) cell lines in the presence or absence of 10 μM nicotinic acid. GNE-617 inhibits NAMPT IC50 of 18.9 nM in A549 cell.The majority of cell lines exhibit a steep dose response to GNE-617 when evaluated by decrease in ATP or total nucleic acid, and the cytotoxicity is completely rescued by simultaneous addition of nicotinic acid. The majority of the cell lines tested have IC₅₀ values below 100 nM, with approximately half with IC₅₀ values less than 10 nM. Eighteen cell lines are not rescued with nicotinic acid, and these non-rescuable cell lines tended to have lower IC₅₀ values (P=0.008, Fisher exact test, IC₅₀<10 nM vs. ≥10 nM).

In Vivo: In rats, GNE-617 hydrochloride (administered QD) and GNE-875 (administered BID) are associated with more severe retinal toxicity at similar exposures and dosing duration compared with GMX-1778 (administered BID). The mouse efficacy studies using GNE-617, GNE-618, and GMX-1778 are designed to assess efficacy and opportunistically used to assess retinal toxicity in mice. NAMPTi retinal toxicity is observed with GNE-617 and GMX-1778; however, the different study durations between GNE-617 and GMX-1778 do not allow for direct comparison of retinal toxicity.

相关产品：Bioactive Compound Library Plus  |  Metabolism/Protease Compound Library  |  Anti-Cancer Compound Library  |  Anti-Lung Cancer Compound Library  |  Human Metabolite Library  |  Heterocyclic Compound Library  |  Highly Selective Inhibitors Library  |  OT-82  |  SBI-797812  |  CB 300919  |  GNE-617  |  NAT  |  Nampt degrader-2  |  GNE-618  |  Nampt-IN-10 trihydrochloride  |  Nampt-IN-5  |  NAMPT degrader-1  |  CB30865  |  GPP78  |  NAMPT inhibitor-linker 2  |  Nampt-IN-1  |  Nampt activator-1  |  Teglarinad chloride  |  LB-60-OF61 hydrochloride  |  STF-118804  |  Nampt-IN-9  |  CHS-828  |  Nampt activator-3  |  LB-60-OF61  |  Nampt-IN-3  |  Nampt-IN-8  |  Nampt-IN-10 TFA  |  Nampt-IN-7  |  (E)-Daporinad  |  Nampt activator-2  |  NAMPT/IDO1-IN-1

热门产品线：重组蛋白  |  化合物库  |  天然产物  |  荧光染料  |  PROTAC  |  同位素标记物  |  寡核苷酸  |  抗体  |  点击化学

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Fluorescent Dye  |  PROTAC  |  Isotope-Labeled Compounds  |  Oligonucleotides  |  Antibodies  |  Click Chemistry

货号: HY-15766A

品牌介绍:
•   MCE (MedChemExpress) 拥有200 多种全球独家化合物库，我们致力于为全球科研客户提供前沿最全的高品质小分子活性化合物；
•   50,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领；
•   产品种类涵盖各种重组蛋白，多肽，常用试剂盒 ，更有 PROTAC、ADC 等特色产品，广泛应用于新药研发、生命科学等科研项目；
•   提供虚拟筛选，离子通道筛选，代谢组学分析检测分析，药物筛选等专业技术服务；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；
•   专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。