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CAS No. : 152520-56-4
MCE 国际站:Nebivolol hydrochloride
产品活性:Nebivolol (R 065824) hydrochloride 是一种 β 受体阻滞剂,具有口服活性和高 β (1)-受体亲和力。Nebivolol hydrochloride 具有直接的血管扩张剂特性和肾上腺素能阻断特性。Nebivolol hydrochloride 可用于高血压、冠状动脉疾病、充血性心力衰竭和缺血性心脏病等多种疾病的研究。
研究领域:GPCR/G Protein | Neuronal Signaling
作用靶点:Adrenergic Receptor
In Vitro: Nebivolol hydrochloride improves endothelial dysfunction via its strong stimulatory effects on the activity of the endothelial nitric oxide synthase and via its antioxidative properties.
?Nebivolol hydrochloride (0.1 μM-10 μM, 1, 2, 4, 7 or 14 days) inhibits haCSMC or haEC proliferation with IC50 values of ~ 6.0 μM.
?Nebivolol hydrochloride (0.1 μM-10 μM, 24 h) induces a moderate rate of apoptosis.
? ?Nebivolol hydrochloride (0.1, 1, 5,10 μM, 4 days)increases NO formation? and decreases endothelin-1 secretion in HaCEs
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货号: HY-B0203A
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