MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

Itraconazole

CAS No. : 84625-61-6

MCE 国际站：Itraconazole

产品活性：Itraconazole (R51211) 是一种三唑类抗真菌药，也是一种有效的口服活性的 Hedgehog 信号通路拮抗剂，IC₅₀ 约为 800 nM。Itraconazole 可有效抑制羊毛甾醇 14α-脱甲基酶 (Cytochrome P450) ，从而抑制羊毛甾醇向麦角固醇的氧化转化。Itraconazole 具有抗癌和抗血管生成作用。 Itraconazole 也是一种 oxysterol-binding protein (OSBP) 抑制剂。

研究领域：Anti-infection  |  Stem Cell/Wnt  |  Metabolic Enzyme/Protease  |  Autophagy

作用靶点：Fungal  |  Hedgehog  |  Cytochrome P450  |  Autophagy  |  Antibiotic  |  Bacterial

In Vitro: Itraconazole has anti-proliferation of HUVEC (IC₅₀ of 0.16 μM).
Itraconazole inhibits endothelial cell cycle progression at the G1 phase in vitro.

In Vivo: Itraconazole (75-100 mg/kg; oral gavage; twice per day; for 18 days; female outbred athymic nude mice) treatment suppresses Hh pathway activity and the growth of medulloblastoma in a mouse allograft model.

相关产品：Drug Repurposing Compound Library Plus  |  FDA-Approved Drug Library Plus  |  FDA-Approved Drug Library Mini  |  Bioactive Compound Library Plus  |  Anti-Infection Compound Library  |  Metabolism/Protease Compound Library  |  Stem Cell Signaling Compound Library  |  Wnt/Hedgehog/Notch Compound Library  |  FDA-Approved Drug Library  |  Anti-Cancer Compound Library  |  Antiviral Compound Library  |  CNS-Penetrant Compound Library  |  Autophagy Compound Library  |  Anti-Aging Compound Library  |  Drug Repurposing Compound Library  |  Antioxidant Compound Library  |  Oxygen Sensing Compound Library  |  Antifungal Compound Library  |  Antibacterial Compound Library  |  NMPA-Approved Drug Library  |  Orally Active Compound Library  |  FDA Approved & Pharmacopeial Drug Library  |  Antibiotics Library  |  Anti-Breast Cancer Compound Library  |  Drug-Induced Liver Injury (DILI) Compound Library  |  Anti-Pancreatic Cancer Compound Library  |  Anti-Liver Cancer Compound Library   |  Rare Diseases Drug Library  |  Anti-Colorectal Cancer Compound Library   |  Children’s Drug Library  |  FDA-Approved Anticancer Drug Library  |  Human Metabolite Library  |  Anti-Prostate Cancer Compound Library  |  Non-steroidal Anti-Inflammatory Compound Library  |  Cancer Stem Cells Compound Library  |  Off-patent Drug Library  |  Membrane Protein-targeted Compound Library  |  Mitochondrial Toxicity Compound Library  |  Antifungal agent 26  |  Myricetin 3-O-α-L-arabinopyranoside  |  (1R,2S,7R)-Sitafloxacin-d₄ hydrochloride  |  Nebacumab  |  Doxorubicin-¹³C,d₃ TFA  |  Gepotidacin  |  Amycolatopsin A  |  PC945  |  Antibiotic A-33853  |  Estradiol hemihydrate  |  Sulbactam-d₂ sodium  |  Antimicrobial agent-5  |  Mephenytoin-d₅  |  NBTIs-IN-4  |  Proanthocyanidins  |  Anticancer agent 120  |  Azlocillin sodium salt  |  Chitin synthase inhibitor 11  |  Antitubercular agent-13  |  AMG-208  |  Toyocamycin  |  Lenampicillin hydrochloride  |  Hispolon  |  PC58538  |  Trifloxystrobin-d₃  |  SPR206 acetate  |  Caracemide  |  Antimicrobial agent-10  |  Doxycycline calcium  |  Antibacterial agent 138

热门产品线：重组蛋白  |  化合物库  |  天然产物  |  荧光染料  |  PROTAC  |  同位素标记物  |  寡核苷酸  |  抗体  |  点击化学

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Fluorescent Dye  |  PROTAC  |  Isotope-Labeled Compounds  |  Oligonucleotides  |  Antibodies  |  Click Chemistry

货号: HY-17514

品牌介绍:
•   MCE (MedChemExpress) 拥有200 多种全球独家化合物库，我们致力于为全球科研客户提供前沿最全的高品质小分子活性化合物；
•   50,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领；
•   产品种类涵盖各种重组蛋白，多肽，常用试剂盒 ，更有 PROTAC、ADC 等特色产品，广泛应用于新药研发、生命科学等科研项目；
•   提供虚拟筛选，离子通道筛选，代谢组学分析检测分析，药物筛选等专业技术服务；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；
•   专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。