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Albendazole

CAS No. : 54965-21-8

MCE 国际站：Albendazole

产品活性：Albendazole (SKF-62979) 是一种口服有效的广谱的抗寄生虫剂，具有高效、低宿主毒性的特点，可用于人类和动物胃肠道寄生虫的研究。Albendazole 可诱导癌细胞的凋亡和自噬，并抗细胞增殖和抑制细胞周期进程。Albendazole 还能抑制微管蛋白的聚合和 HIF-1α、VEGF 的表达，具有抗氧化活性，能抑制癌细胞的糖酵解过程。

研究领域：Anti-infection  |  Cytoskeleton  |  Cell Cycle/DNA Damage  |  Autophagy  |  Apoptosis  |  Immunology/Inflammation  |  NF-κB  |  Metabolic Enzyme/Protease  |  Protein Tyrosine Kinase/RTK

作用靶点：Parasite  |  Microtubule/Tubulin  |  Autophagy  |  Apoptosis  |  Reactive Oxygen Species  |  VEGFR  |  HIF/HIF Prolyl-Hydroxylase  |  Antibiotic  |  Bacterial

In Vitro: Albendazole (100, 500, 1000 nM; 1, 3, or 5 days) inhibits cell proliferation in a dose-dependent manner.
Albendazole (100, 250, 500, 1000 nM; 3 days) arrests SKHEP-1 cells at both G0–G1 (250, 500 nM) and G2-M (1000 nM) phases of the cycle.
Albendazole (5 µM; 24, 36 h) mainly induces early apoptosis in HCT-15 cells and late apoptosis in HCT-1 16, HT29, SW480 cells accompanied with cleavage of PARP and caspase-3 in a time-dependent manner.
Albendazole (5 µM; 24, 36 h) induces autophagy via increasing autophagy-related protein (such as LC3, Atg7, p-beclin-1, and beclin-1) expression level in HCT-15, HCT-1 16, HT29, and SW480 cells.
Albendazole (500 nM, 24 h) inhibits hypoxia-induced HIF-1α expression and VEGF expression in A549 cells.

In Vivo: Albendazole (10 mg/kg; i.g.; once a day for 30 days) reduces Echinococcus granulosus cyst weights in mice.
Albendazole (300 mg/kg; p.o.; per day in two divided dose for 20 days) profoundly suppresses tumor growth in vivo.

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货号: HY-B0223

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