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Sulfamethoxazole

CAS No. : 723-46-6

MCE 国际站：Sulfamethoxazole

产品活性：Sulfamethoxazole (Ro 4-2130) 是磺胺类抗菌素，用于细菌感染。Sulfonamides 是对氨基苯甲酸 (PABA) 的竞争性拮抗剂。

研究领域：Anti-infection

作用靶点：Bacterial  |  Antibiotic

In Vitro: Sulfonamides are structural analogs and competitive antagonists of para-aminobenzoic acid (PABA). They inhibit normal bacterial utilization of PABA for the synthesis of folic acid, an important metabolite in DNA synthesis.? The effects seen are usually bacteriostatic in nature. Folic acid is not synthesized in humans, but is instead a dietary requirement. This allows for the selective toxicity to bacterial cells (or any cell dependent on synthesizing folic acid) over human cells. Bacterial resistance to sulfamethoxazole is caused by mutations in the enzymes involved in folic acid synthesis that prevent the drug from binding to it.

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