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Dipyridamole

CAS No. : 58-32-2

MCE 国际站：Dipyridamole

产品活性：Dipyridamole (Persantine) 是具有口服活性的磷酸二酯酶 (PDE) 抑制剂，能阻断红细胞和血管内皮细胞对腺苷的吸收和代谢。Dipyridamol 也是一种用于脑卒中二级预防的抗血小板剂。Dipyridamol 可诱导肿瘤细胞特异性凋亡。

研究领域：Metabolic Enzyme/Protease  |  Apoptosis

作用靶点：Phosphodiesterase (PDE)  |  Apoptosis

In Vitro: Dipyridamole (5 μM; 15 min) results in a 2.5-fold increase in intracellular cAMP levels in OCI-AML-3 cells.
Dipyridamole (5 μM; 48 h) with the statin combination induces apoptosis in primary AML cells.
Dipyridamole (5 μM; 48 h) possesse cAMP/PKA-independent activity against statininduced SREBP2 activation.

In Vivo: Dipyridamole (10 mg/kg; p.o. once daily for 18 d) mitigates tumor growth, ameliorated concurrent alterations in blood circulation and tumor tissues, and platelet infiltration in tumor tissues.

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