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CAS No. : 15318-45-3
MCE 国际站:Thiamphenicol
产品活性:Thiamphenicol (Thiophenicol) 是 Chloramphenicol 的甲基磺酰基衍生物,是一种广谱抗菌类抗生素。Thiamphenicol 通过与 50S 核糖体亚基结合而起作用,使蛋白质合成被抑制并具有抑菌作用 (针对革兰氏阴性,革兰氏阳性需氧和厌氧菌)。
研究领域:Anti-infection
作用靶点:Bacterial | Antibiotic
In Vitro: Thiamphenicol shows a significant post-antibiotic effect (PAE) (0.33 to 2.9h) on all pathogens studied (S. pneumoniae, S. aureus and Escherichia coli) and a powerful bactericidal effect against β-lactamase-positive and -negative H. influenzae. Thiamphenicol MICs for the microorganisms analyzed are: 32 mg/L (S. aureus and E. coli), 2 mg/L (S. pneumoniae) and 0.25 mg/L (H. influenzae). Thiamphenicol shows a good in vitro activity against difficult-to-treat multiply resistant pathogens.
In Vivo: The pharmacokinetics of Thiamphenicol (30 mg/kg) after single intravenous (IV) and oral (PO) administration is investigated in Mulard ducks. After IV administration, for Thiamphenicol, the mean residence time is 2.83 hours, the general half-life is 1.96 hours, the clearance is 0.04 L/hr/kg. Pharmacokinetics after PO administration is very similar for IV administration. Thiamphenicol shows rapid absorption and bioavailability of more than 70%.
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货号: HY-B0479
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