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Quinoclamine

CAS No. : 2797-51-5

MCE 国际站：Quinoclamine

产品活性：Quinoclamine 是一种萘醌衍生物，是一种 NF-κB 抑制剂。Quinoclamine 具有抗肿瘤活性。

研究领域：NF-κB

作用靶点：NF-κB

In Vitro: Quinoclamine causes differentiation of U-937 cells into macrophage-like cells.
Quinoclamine inhibits NF-κB activities in HepG2 cells, with an IC₅₀ of 1.7 μM.
Quinoclamine (1-4 μM; 30 minutes ) suppresses endogenous NF-κB activity in HepG2 cells through the inhibition of IκB-α phosphorylation and p65 translocation.
Quinoclamine inhibits induced NF-κB activities in lung and breast cancer cell lines.
Quinoclamine affects the expression levels of genes involved in cell cycle or apoptosis.
Quinoclamine down-regulates the expressions of UDP glucuronosyltransferase genes involved in phase II drug metabolism.

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