MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

AZD7325

CAS No. : 942437-37-8

MCE 国际站：AZD7325

产品活性：AZD7325 是具有口服活性的 α2,3 receptor 的正向别构调节剂 (PAM)，K_i 分别是 0.3 and 1.3 nM，但在 α1 和 α5 受体亚型上效果较差。AZD7325 是一种中等 CYP1A2 和强效 CYP3A4 诱导剂。AZD7325 具有用于焦虑和 dravet 综合征相关研究的潜力。

研究领域：Membrane Transporter/Ion Channel  |  Neuronal Signaling  |  Metabolic Enzyme/Protease

作用靶点：GABA Receptor  |  Cytochrome P450

In Vitro: AZD7325 is a high affinity and selective modulator of the GABAA receptor system, exhibits high binding affinity at GABAAα1, α2 and α3 (K_i=0.5, 0.3, and 1.3 nM, respectively), and low at GABAAα5 (K_i=230 nM).
AZD7325 (0-10 µM; 3 consecutive days; once daily) causes a maximal CYP1A2 mRNA expression of 3.2-fold, 2.1-fold, and 2.5-fold in human hepatocytes from donor HH210, HH215, and HH216, respectively.
AZD7325 (0-10 µM; 3 consecutive days; once daily) causes CYP1A2 and CYP3A4 protein expression in human hepatocytes from donor HH210.

In Vivo: AZD7325 (oral administration; 10, 17.8 or 31.6 mg/kg; 30 minutes before the induction of hyperthermia) attenuates hyperthermia-induced seizures, shows median thresholds in the treatment groups of 42.8°C for 10 mg/kg, 43.3°C for 17.8 mg/kg, and 43.4°C for 31.6 mg/kg compares to 42.2°C in vehicle group.

相关产品：Drug Repurposing Compound Library Plus  |  Clinical Compound Library Plus  |  Bioactive Compound Library Plus  |  Immunology/Inflammation Compound Library  |  Membrane Transporter/Ion Channel Compound Library  |  Metabolism/Protease Compound Library  |  Neuronal Signaling Compound Library  |  Clinical Compound Library  |  Anti-Aging Compound Library  |  Drug Repurposing Compound Library  |  Antioxidant Compound Library  |  Oxygen Sensing Compound Library  |  Orally Active Compound Library  |  Neurotransmitter Receptor Compound Library  |  Anti-Alzheimer's Disease Compound Library  |  Neuroprotective Compound Library  |  Anti-Parkinson's Disease Compound Library  |  Neurodegenerative Disease-related Compound Library  |  Antidepressant Compound Library  |  GABA Receptor Compound Library  |  Human Metabolite Library  |  Membrane Protein-targeted Compound Library  |  Membrane Receptor-targeted Compound Library  |  Highly Selective Activators Library  |  SKF89976A hydrochloride  |  PC945  |  Mephenytoin-d₅  |  AMG-208  |  rac-BHFF  |  Tiagabine hydrochloride hydrate  |  Lesogaberan napadisylate  |  Doxepin-d₃ hydrochloride  |  (2S)-6-Prenylnaringenin  |  Hypericin  |  EMT inhibitor-2  |  GABAB receptor antagonist 1  |  Atazanavir  |  FG8119  |  3α,21-Dihydroxy-5α-pregnan-20-one  |  ZK 93423  |  Bicuculline methiodide  |  CGP35348  |  Galeterone  |  (-)-α-Pinene  |  γ-Acetylenic GABA  |  CYP1B1-IN-2  |  Picrotoxinin  |  Bergapten  |  Fadrozole hydrochloride  |  Ginsenoside Rd  |  Chrodrimanin B  |  GABAA receptor agent 2 TFA  |  ML252  |  3α,21-Dihydroxy-5α-pregnan-20-one-d₃

热门产品线：重组蛋白  |  化合物库  |  天然产物  |  荧光染料  |  PROTAC  |  同位素标记物  |  寡核苷酸  |  抗体  |  点击化学

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Fluorescent Dye  |  PROTAC  |  Isotope-Labeled Compounds  |  Oligonucleotides  |  Antibodies  |  Click Chemistry

货号: HY-111052

品牌介绍:
•   MCE (MedChemExpress) 拥有200 多种全球独家化合物库，我们致力于为全球科研客户提供前沿最全的高品质小分子活性化合物；
•   50,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领；
•   产品种类涵盖各种重组蛋白，多肽，常用试剂盒 ，更有 PROTAC、ADC 等特色产品，广泛应用于新药研发、生命科学等科研项目；
•   提供虚拟筛选，离子通道筛选，代谢组学分析检测分析，药物筛选等专业技术服务；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；
•   专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。