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CAS No. : 1383478-94-1
MCE 国际站:CYM 9484
产品活性:CYM 9484 是一种选择性强效神经肽 Y (NPY) Y2 受体拮抗剂,IC50 值为 19 nM。
研究领域:GPCR/G Protein | Neuronal Signaling
作用靶点:Neuropeptide Y Receptor
In Vitro: SF-11 is a selective, brain-penetrant NPY Y2 receptor antagonist with an IC50 value of 190 nM. Systematically explore the SAR of the hit molecule SF-11 that leads to the identification of selective and highly potent small molecule NPY Y2 receptor antagonist CYM 9484 (Compound 16). CYM 9484 is 10-fold more potent than the hit molecule SF-11. CYM 9484 is prepared by the coupling of α,α-diphenylpiperidino-4-methanol with a variety of aryl isothiocyanates.
相关产品:Bioactive Compound Library Plus | GPCR/G Protein Compound Library | Neuronal Signaling Compound Library | Neurotransmitter Receptor Compound Library | Anti-Obesity Compound Library | Targeted Diversity Library | Heterocyclic Compound Library | Membrane Protein-targeted Compound Library | Membrane Receptor-targeted Compound Library | Highly Selective Inhibitors Library | Neuropeptide Y (3-36) (porcine) | CART(55-102)(rat) | Galanin (1-16), mouse, porcine, rat | RFRP-1(human) TFA | Spexin | Galanin Receptor Ligand M35 TFA | RFRP-1(human) | CART(55-102)(human) | RTI-118 | RF9 | [Leu31,Pro34]-Neuropeptide Y(human,rat) TFA | SF 11 | RFRP-3(human) TFA | M1145 TFA | (Leu31,Pro34)-Peptide YY (human) | Galantide | Neuropeptide Y (18-36) (porcine) | Neuropeptide Y (human) (TFA) | NTNCB hydrochloride | M40 | Neuropeptide S(Rat) TFA | FR252384 | BIBP3226
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