MCE 的所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务。
CAS No. : 2004677-13-6
MCE 国际站:Selgantolimod
产品活性:Selgantolimod (GS-9688) 是一种口服活性,有效和选择性的 Toll 样受体 8 (TLR8) 激动剂,用于乙型肝炎病毒 (HBV) 和 HIV 感染的研究。
研究领域:Immunology/Inflammation | Anti-infection
作用靶点:Toll-like Receptor (TLR) | HBV
In Vitro: Selgantolimod induces the cellular immune mediators interleukin (IL)-12 and IL-8, as well as the antiviral cytokines tumor necrosis factor-α and IFN-γ in vitro in human perpheral blood mononuclear cells.
Selgantolimod activates natural killer (NK) and mucosal associated invariant T cells, stimulates cluster of differentiation (CD)-8+ T-cell proliferation, and increas IFNγ production, while lowering programmed cell death protein 1 expression by HBV-specific CD8+-T cells in vitro in peripheral blood mononuclear cells.
Selgantolimod-induced cytokines reduce HBV DNA, RNA, and antigen levels in HBV-infected primary human hepatocytes.
In Vivo: Once-weekly dosing of oral Selgantolimod induces dose-dependent increases in serum IL-12 and IL-1 receptor antagonist (IL-1RA) in cynomolgus monkeys, and leads to functional cure in the woodchuck model of chronic HBV.
相关产品:Drug Repurposing Compound Library Plus | Clinical Compound Library Plus | Bioactive Compound Library Plus | Anti-Infection Compound Library | Immunology/Inflammation Compound Library | Clinical Compound Library | Antiviral Compound Library | Small Molecule Immuno-Oncology Compound Library | Drug Repurposing Compound Library | Antioxidant Compound Library | Reprogramming Compound Library | Oxygen Sensing Compound Library | Pyroptosis Compound Library | Heterocyclic Compound Library | Pain-Related Compound Library | Membrane Protein-targeted Compound Library | Membrane Receptor-targeted Compound Library | Highly Selective Inhibitors Library | Highly Selective Activators Library | C29 | ODN 1018 | TLR7 agonist 5 | FNC-TP | Tuvirumab | AN-3485 | ODN 2088 | Bicyclol | TLR4/NF-κB/MAPK-IN-1 | Catalpol | (5S,8R)-HBV-IN-10 | Glycosmisic acid | RO8191 | TLR9-IN-1 | Adefovir-d4 | Swertianolin | Complete Freund's adjuvant (CFA) | ODN 105871 | Tiviciclovir | MC-Val-Cit-PAB-Amide-TLR7 agonist 4 | Monophosphoryl lipid A | (1R)-Tenofovir amibufenamide | 2'-Deoxy-L-adenosine | HBV-IN-13 | AB-423 | Brain Derived Basic Fibroblast Growth Factor (1-24) | β-D-Glucan | Pseudolaric Acid B | Poly (I:C):Kanamycin (1:1) (sodium) | Canocapavir
热门产品线:重组蛋白 | 化合物库 | 天然产物 | 荧光染料 | PROTAC | 同位素标记物 | 寡核苷酸 | 抗体 | 点击化学
Trending products:Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Fluorescent Dye | PROTAC | Isotope-Labeled Compounds | Oligonucleotides | Antibodies | Click Chemistry
货号: HY-109137
品牌介绍:
• MCE (MedChemExpress) 拥有200 多种全球独家化合物库,我们致力于为全球科研客户提供前沿最全的高品质小分子活性化合物;
• 50,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领;
• 产品种类涵盖各种重组蛋白,多肽,常用试剂盒 ,更有 PROTAC、ADC 等特色产品,广泛应用于新药研发、生命科学等科研项目;
• 提供虚拟筛选,离子通道筛选,代谢组学分析检测分析,药物筛选等专业技术服务;
• 设有专业的实验中心和严格的质控、验证体系;
• 提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告,确保产品的高纯度、高品质;
• 产品的生物活性多经各国客户实验验证;
• Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果;
• 专业团队跟踪最新的制药及生命科学研究进展,为您提供全球最新的活性化合物;
• 与世界各大制药公司及知名科研机构建立了长期的合作。