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CAS No. : 134865-74-0
MCE 国际站:4-P-PDOT
产品活性:4-P-PDOT 是一种有效的,选择性的和亲和性的褪黑激素受体 (MT2) 拮抗剂。4-P-PDOT 对 MT2 的选择性是 MT1 的 300 倍以上。4-P-PDOT 可显着抵消褪黑激素介导的抗氧化作用 (GSH/GSSG比,ERK 磷酸化,Nrf2 核易位,Nrf2 DNA 结合活性)。
研究领域:GPCR/G Protein | Neuronal Signaling
作用靶点:Melatonin Receptor
In Vitro: In CHO-mt1 cells the amidotetraline 4-P-PDOT (10 mM) has no effect on forskolin-stimulated cyclic AMP levels, either alone, or in the presence of Melatonin. In contrast, in CHO-MT2 cells, 4-P-PDOT is an agonist, producing a concentration-dependent inhibition of forskolin stimulated cyclic AMP, with a pEC50 value of 8.72 and intrinsic activity of 0.86.
In Vivo: 4-P-PDOT (0.5-1.0 mg/kg; intravenous injection; klotho mutant mice) treatment significantly reverses antioxidant effects mediated by Melatonin. And significantly reverses the changes in the levels of these GSH-related parameters. 4-P-PDOT treatment significantly reverses the memory function of Melatonin-treated klotho mutant mice. 4-P-PDOT also counteracts Melatonin-mediated attenuation in response to the decreases in phospho-ERK expression, Nrf2 nuclear translocation, Nrf2 DNA-binding activity, and GCL mRNA expression in the hippocampi of klotho mutant mice.
相关产品:Bioactive Compound Library Plus | GPCR/G Protein Compound Library | Neuronal Signaling Compound Library | NF-κB Signaling Compound Library | Antioxidant Compound Library | Targeted Diversity Library | Human Metabolite Library | Cuproptosis Compound Library | Membrane Protein-targeted Compound Library | Membrane Receptor-targeted Compound Library | Highly Selective Inhibitors Library | Ramelteon metabolite M-II-d3 | 2-Iodomelatonin | Melatonin-d3 | Melatonin receptor agonist 1 | 7-Desmethyl-3-hydroxyagomelatine | Agomelatine-d4 | Agomelatine-d6 | S-22153 | S26131 | TIK-301 | Ramelteon metabolite M-II | Melatonin-d7 | Tasimelteon-d5 | Ramelteon | Antidepressant agent 4 | N-Acetyltryptamine | 6-Chloromelatonin | Luzindole | Agomelatine (L(+)-Tartaric acid) | Agomelatin-d3 | ACH-000143 | 8-M-PDOT | Ramelteon-d3 | Antidepressant agent 3
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