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CAS No. : 87233-61-2
MCE 国际站:Emedastine
产品活性:Emedastine 是一种具有口服活性,选择性和高亲和力的组胺 H1 受体拮抗剂,Ki 值为 1.3 nM。Emedastine 是一种苯并咪唑衍生物,具有强大的抗过敏特性,可用于过敏性鼻炎,过敏性皮肤疾病和过敏性结膜炎。
研究领域:GPCR/G Protein | Neuronal Signaling | Immunology/Inflammation
作用靶点:Histamine Receptor
In Vitro: Emedastine inhibits histamine H2 receptor (Ki=49067 nM) and histamine H3 receptor (Ki=12430 nM).
High concentrations of Emedastine (1 and 10 ng/ml) significantly inhibits type 1 collagen production in normal human dermal fibroblasts.
Emedastine (1, 10, 100, 1000 nM) at concentrations of ≥ 10 nM inhibits CC chemokine-elicited eosinophil migration.
In Vivo: Emedastine (0.03, 0.1, 0.3 mg/kg; orally; pretreatment of 30 min) significantly suppresses histamine-induced scratching with 0.1 and 0.3 mg/kg but not 0.03 mg/kg.
Pretreatment with Emedastine (0.03, 0.1, 0.3 mg/kg; orally) significantly inhibits the scratching induced by substance P and leukotriene B.
Emedastine (0.3 mg/kg, p.o.) produces significant inhibition of passive peritoneal anaphylaxis in guinea-pigs.
Emedastine inhibits histamine-induced contractions of isolated ileum (IC50=6.1 nM).
相关产品:Drug Repurposing Compound Library Plus | FDA-Approved Drug Library Plus | FDA-Approved Drug Library Mini | Bioactive Compound Library Plus | GPCR/G Protein Compound Library | Immunology/Inflammation Compound Library | Neuronal Signaling Compound Library | FDA-Approved Drug Library | Drug Repurposing Compound Library | NMPA-Approved Drug Library | Orally Active Compound Library | Neurotransmitter Receptor Compound Library | FDA Approved & Pharmacopeial Drug Library | Anti-Parkinson's Disease Compound Library | Neurodegenerative Disease-related Compound Library | Anti-Obesity Compound Library | EMA-Approved Drug Library | Human Metabolite Library | Coagulation and Anti-coagulation Compound Library | Off-patent Drug Library | Membrane Protein-targeted Compound Library | Membrane Receptor-targeted Compound Library | Highly Selective Inhibitors Library | Perphenazine-d8 dihydrochloride | Zotepine | Emedastine difumarate | Cipralisant (enantiomer) | Doxepin-d3 hydrochloride | ST-1006 | Chlorphenoxamine | Clemastine-d5 fumarate | H3 receptor-MO-1 | Izuforant | ABT-239 | Fexofenadine | Ketotifen fumarate | S 38093 | Roxatidine | Histamine phosphate | Ciproxifan maleate | LML134 | Olopatadine-d3 hydrochloride | JNJ10191584 maleate | (Z)-Olopatadine-d3 hydrochloride | Cetirizine | Cinitapride | ICI 162846 | Diphenylpyraline hydrochloride | Doxylamine-d5 | Cyclizine lactate | FRG8701 | Methdilazine hydrochloride | Azelastine hydrochloride
热门产品线:重组蛋白 | 化合物库 | 天然产物 | 荧光染料 | PROTAC | 同位素标记物 | 寡核苷酸 | 抗体 | 点击化学
Trending products:Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Fluorescent Dye | PROTAC | Isotope-Labeled Compounds | Oligonucleotides | Antibodies | Click Chemistry
货号: HY-108411
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