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CAS No. : 63612-50-0
MCE 国际站:Nilutamide
产品活性:Nilutamide (Nilandron) 是一种口服活性的非甾体雄激素受体拮抗剂,对雄激素受体有亲和力,但对孕激素、雌激素或糖皮质激素受体无亲和力。Nilutamide 可用于研究前列腺癌。Nilutamide 还具有抗血吸虫作用。
研究领域:Vitamin D Related/Nuclear Receptor | Anti-infection
作用靶点:Androgen Receptor | Parasite
In Vitro: Nilutamide (110 μM) inhibits hexobarbital hydroxylase, benzphetamine N-demethylase, benzo(a)pyrene hydroxylase and 7-ethoxycoumarin O-deethylase activities by 85, 40, 35 and 25%, respectively, in human liver microsomes.
Nilutamide (550 μM) does not significantly increase the consumption of NADPH by aerobic microsomes, and does not modify the kinetics for the reduction of cytochrome P-450 by NADPH-cytochrome P-450 reductase in an anaerobic system.
Nilutamide blocks the marked increase in GCDFP-15 release induced by 1 nM testosterone in T-47D cells and ZR-75-1 cells with IC50s of 87 nM and 75 nM, respectively.
In Vivo: Nilutamide (50-400 mg/kg; p.o.; single dosage) reduces juvenile and adult Schistosoma mansoni cercariae worm burdens in infected mice.
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货号: HY-13702
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