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Hematein

CAS No. : 475-25-2

MCE 国际站：Hematein

产品活性：Hematein 是苏木精的氧化产物，可作为染料。Hematein 是一种变构酪蛋白激酶 II 抑制剂，IC₅₀ 为 0.74 μM。Hematein 抑制 Akt/PKB Ser129 磷酸化，Wnt/TCF 途径并增加肺癌细胞的凋亡。

研究领域：Cell Cycle/DNA Damage  |  Stem Cell/Wnt  |  PI3K/Akt/mTOR  |  Apoptosis

作用靶点：Casein Kinase  |  Akt  |  Wnt  |  Apoptosis

In Vitro: Hematein (10-100 μM; 14 days) inhibits cells growth in A427 lung cancer cells.
Hematein (50 and 100 μM; 48 hours) induces apoptosis in A427 lung cancer cells.
Hematein (50 and 100 μM; 48 hours) inhibits CK2-specific Akt phosphorylation.

In Vivo: Hematein (intraperitoneal injections; 50 mg/kg; twice a week for 6 weeks) inhibits tumor growth in A427 lung cancer cell xenografts.

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