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CORM-401

CAS No. : 1001015-18-4

MCE 国际站：CORM-401

产品活性：CORM-401 是一种对氧化剂敏感的 CO 释放分子。CORM-401 诱导内皮钙信号调节中的 NO 增加。CORM-401 减少 TNF-α/CHX 和 H2O2 诱导的 ROS 产生。CORM-401 解耦线粒体呼吸并抑制糖酵解。

研究领域：Immunology/Inflammation  |  NF-κB  |  Metabolic Enzyme/Protease

作用靶点：Reactive Oxygen Species

In Vitro: CORM-401 (100 µM; 1h) induces the NO production in endothelial EA.hy926 cells.
CORM-401 (30 µM) induces peak-like calcium signal and augmentes coupling of endoplasmic reticulum and plasmalemmal store-operated calcium channels.
CORM-401 (50 µM; 1h) significantly reduces TNF-α/CHX and H2O2-induced ROS production and cell death.
CORM-401 (0.5, 1 mM) induces a persistent increase in the oxygen consumption rate in endothelial EA.hy926 cells.
CORM-401 (10, 30, 100 µM) induces a concentration-dependent increase in OCR and a simultaneous decrease in ECAR.

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