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CAS No. : 1337531-06-2
MCE 国际站:GSK2593074A
产品活性:GSK2593074A (GSK’074) 是一种程序性坏死 (necroptosis) 抑制剂, 抑制 RIP1 和 RIP3。
研究领域:Apoptosis
作用靶点:RIP kinase
In Vitro: GSK2593074A (GSK’074; 0.01, 0.1, 1, 10, and 100 nM; 6 hours for MOVAS cells; 3 hours for L929 cells) completely rescues cells from necroptosis under different stimuli in both human and murine cells at IC50~3 nM. In multiple cell types including mouse SMCs, fibroblasts (L929), bone marrow derived macrophages (BMDM), and human colon epithelial cells (HT29), GSK2593074A inhibits necroptosis with an IC50 of ~3 nM.
In Vivo: GSK2593074A (GSK’074; 0.93 mg/kg/day; i.p. injection; 14 or 28 days) is administrated to Apoe-/- mice immediately following pump implantation. Compared to the DMSO group, GSK2593074A-treated mice show significantly alleviated aneurysm formation, reflected by a much smaller aortic dilatation (DMSO 85.39±15.76% vs GSK2593074A 36.28±5.76%; P<0.05) as well as a reduced abdominal aortic aneurysm (AAA) incidence (from 83.3 to 16.7%). GSK2593074A significantly decreases the extent of aortic expansion (DMSO 66.06±9.17% vs GSK2593074A 27.36±8.25%; P<0.05) .
相关产品:Bioactive Compound Library Plus | Apoptosis Compound Library | Immunology/Inflammation Compound Library | Kinase Inhibitor Library | NF-κB Signaling Compound Library | Membrane Protein-targeted Compound Library | RIPA-56 | RIPK1-IN-3 | RIP1 kinase inhibitor 1 | Desmethyl-WEHI-345 analog | RIP2 kinase inhibitor 2 | PROTAC RIPK degrader-6 | TP-030-1 | PK68 | RIPK1-IN-4 | MLKL-IN-4 | NecroIr2 | RIPK1-IN-14 | Oditrasertib | cRIPGBM chloride | KWCN-41 | GSK963 | AV123 | RIP2 Kinase Inhibitor 4 | Necrostatin 2 | RIPK1-IN-11 | RIP1 kinase inhibitor 5 | ICCB-19 hydrochloride | RIPK3-IN-2 | GSK2983559 active metabolite | OD36 | RIP2 kinase inhibitor 1 | GSK840 | RIPK1-IN-15 | Necroptosis-IN-1
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货号: HY-122909
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