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CAS No. : 496054-87-6
MCE 国际站:Radiprodil
产品活性:Radiprodil (RGH-896) 是具有口服活性的、NMDA 受体 NR2B 亚类的选择性拮抗剂。Radiprodil 有潜力用于神经性疼痛和其它慢性疼痛的相关研究。
研究领域:Membrane Transporter/Ion Channel | Neuronal Signaling
作用靶点:iGluR
In Vitro: Preincubation with Radiprodil (10 nM) restores long-term potentiation (LTP) in the presence of Aβ1-42, 3NTyr10-Aβ and Aβ1-40, but not AβpE3.
As for LTP, Radiprodil (10 nM) reverses the synaptic toxicity of 3NTyr-AβAβ1-40 and Aβ1-42 but not that AβpE3-42.
In Vivo: Radiprodil could block NMDA currents in Mg2+ insensitive variants, with potencies similar to those obtained without Mg2+.
Radiprodil's potency is higher at pH 7.0 than at pH 7.6, suggesting that radiprodil may retain its ability to block glutamate-induced NMDA currents even under acidic conditions that manifest under long term seizures.
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货号: HY-14777
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