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MW-150

CAS No. : 1628502-91-9

MCE 国际站：MW-150

产品活性：MW-150 (MW01-18-150SRM) 是一种选择性，口服有效的，可透过神经系统的 p38α MAPK 抑制剂，K_i 值为 101 nM。MW-150 抑制内源性 p38α MAPK 在活化的神经胶质中磷酸化内源性底物 MK2 的能力。

研究领域：MAPK/ERK Pathway  |  Autophagy

作用靶点：p38 MAPK  |  Autophagy

In Vitro: MW-150 inhibits in a concentration-dependent manner the ability of the endogenous p38α MAPK to phosphorylate an endogenous substrate MK2 in activated glia.
MW-150 blocks in a concentration-dependent manner the increased IL-1β production by activated glia. The IC₅₀ values are 332 nM and 936 nM for MK2 and IL-1β, respectively.

In Vivo: MW-150 (2.5 mg/kg; oral daily for 3-4 months) improves the APP/PS1 transgenic (Tg) mice performance in radial arm water maze (RAWM) and contextual fear conditioning tests.
MW-150 (2.5 mg/kg; given i.p.; daily for 14 days) treatment in APP^NLh/NLh × PS^P264L/P264L knock-in mouse (with no overexpression of the amyloid precursor protein) exhibits RAWM behavior indistinguishable from WT mice.

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