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STAT3-IN-3

CAS No. : 2361304-26-7

MCE 国际站：STAT3-IN-3

产品活性：STAT3-IN-3 是一种有效和选择性的 STAT3 抑制剂，有抗增殖活性。STAT3-IN-3 可以引起乳腺癌细胞凋亡 (apoptosis)。STAT3-IN-3 是有前途的靶向线粒体的 STAT3 抑制剂，能用于癌症的研究。

研究领域：JAK/STAT Signaling  |  Stem Cell/Wnt  |  Apoptosis

作用靶点：STAT  |  Apoptosis

In Vitro: STAT3-IN-3 has no influence on the phosphorylation levels of STAT1, JAK2, Src and Erk1/2.
STAT3-IN-3 inhibits the growth of MDA-MB-231, HCT-116, HepG2, and MCF-7 cells with IC₅₀s of 1.43 μM, 1.89 μM, 2.88 μM, and 3.33 μM, respectively.
STAT3-IN-3 down-regulates the expression of STAT3 target genes Bcl-2 and Cyclin D1.
STAT3-IN-3 inhibits STAT3 tyrosine phosphorylation and serine phosphorylation.
STAT3-IN-3 inhibits STAT3 DNA-binding activity.
STAT3-IN-3 (1-4 μM; 24 hours) increases ROS production and remarkably reduces the mitochondrial membrane potential to induce mitochondrial apoptotic pathway.
STAT3-IN-3 (1-4 μM; 24 hours) can induce the cleavage of caspase-9, caspase-3 and PARP.

In Vivo: STAT3-IN-3 (10mg/kg-20 mg/kg; i.p.; daily; for 14 days) possesses potent antitumor activity against implanted 4T1 breast tumors growth.

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