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Guanfacine hydrochloride

CAS No. : 29110-48-3

MCE 国际站：Guanfacine hydrochloride

产品活性：Guanfacine (hydrochloride) 是一种去甲肾上腺素能 α2A 激动剂，具有口服活性，对 α2A 受体亚型具有高度选择性。Guanfacine 具有产生低血压和镇静作用。Guanfacine 可用于研究多种 PFC 认知障碍，包括妥瑞氏综合征和注意力缺陷多动障碍 (ADHD)。

研究领域：GPCR/G Protein  |  Neuronal Signaling

作用靶点：Adrenergic Receptor

In Vitro: Guanfacine (hydrochloride) increases the delay-related neuronal firing needed for working memory on dIPFC neurons at the cellular level.
Guanfacine improves PFC cognitive function by inhibiting the production of CAMP, closing HCN channels, and strengthening the PFC networks.

In Vivo: Guanfacine (hydrochloride) enhances PFC working memory function in aged monkeys and improves impulse control in monkeys performing a delayed discounting task.
Guanfacine improves cognitive performance when infused directly into the rat or monkey PFC.
Guanfacine blocks 2A receptors in the monkey dIPFC markedly impairs working memory, behavioral inhibition and greatly reduces persistent neuronal firing.

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