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ZM323881 hydrochloride

CAS No. : 193000-39-4

MCE 国际站：ZM323881 hydrochloride

产品活性：ZM323881 hydrochloride 是有效，选择性的 VEGFR2 抑制剂， IC₅₀ 值小于2 nM。

研究领域：Protein Tyrosine Kinase/RTK

作用靶点：VEGFR

In Vitro: ZM323881 is an anilinoquinazoline that potently inhibits VEGFR2 (KDR) tyrosine kinase activity anddemonstrates excellent selectivity versus other receptor tyrosine kinases, including PDGFRβ, FGFR1, EGFR and erbB2 (IC₅₀>50 μM). ZM323881 inhibits VEGF-A-induced endothelial cell proliferation(IC₅₀=8 nM) and VEGFR2 tyrosine phosphorylation. ZM323881 inhibits activation of VEGFR-2, but not of VEGFR-1, epidermal growth factor receptor (EGFR), platelet-derived growth factor receptor (PDGFR), or hepatocyte growth factor (HGF) receptor. In HAECs, ZM323881 completely inhibits VEGF-induced ERK phosphorylation at 1 μM

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