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CGK733

CAS No. : 905973-89-9

MCE 国际站：CGK733

产品活性：CGK733 是一种有效的 ATM/ATR 抑制剂，用于癌症研究。

研究领域：Cell Cycle/DNA Damage  |  PI3K/Akt/mTOR

作用靶点：ATM/ATR

In Vitro: CGK733 (4.2 ng/μL-12.5 ng/μL) enhances taxol-induced cytotoxicity in HBV-positive HCC cells. CGK733 (4.2 ng/μL) accelerates the formation of multinucleated cells and promotes the exit of mitosis in taxol-treated HBV-positive HCC cells. CGK733 (10 μM) causes the loss of cyclin D1 through the ubiquitin-dependent proteasomal degradation pathway in MCF-7 and T47D breast cancer cell lines. CGK733 (0.6-40 μM) shows inhibitory activities against proliferation of LnCap prostate cancer cells, HCT116 colon cancer cells, MCF-7 and T47D estrogen receptor positive breast cancer cells, and MDA-MB436 ER negative breast cancer cells. Moreover, CGK733 inhibits proliferation of non-transformed mouse BALB/c 3T3 embryonic fibroblast cells. In addition, CGK733 (10 μM) inhibits MCF-7 proliferation, and the effect can not be suppressed by pan-caspase inhibition. CGK733 (10 μM) results in 1.6-fold increase in ATM reporter activity in HEK-293 cells.

In Vivo: CGK733 (25 mg/kg, i.p.) increases the ATM reporter activity (reports inactivation of ATM kinase activity) compared to control mice, with 2.4-fold, 3.1-fold, and 1.3-fold changes at 1, 4, and 8 hours, respectively.

相关产品：Bioactive Compound Library Plus  |  Cell Cycle/DNA Damage Compound Library  |  Kinase Inhibitor Library  |  PI3K/Akt/mTOR Compound Library  |  Anti-Cancer Compound Library  |  Anti-Aging Compound Library  |  Oxygen Sensing Compound Library  |  Glycolysis Compound Library  |  Cytoskeleton Compound Library  |  Anti-Breast Cancer Compound Library  |  Anti-Pancreatic Cancer Compound Library  |  Anti-Cancer Metabolism Compound Library  |  Anti-Obesity Compound Library  |  Glucose Metabolism Compound Library  |  Cancer Stem Cells Compound Library  |  Tuvusertib  |  Elimusertib  |  AZD1390  |  Ceralasertib  |  AZD-7648  |  KU 59403  |  VE-821  |  KU-55933  |  ATM Inhibitor-3  |  Elimusertib-d₃  |  ATR-IN-22  |  ATR-IN-6  |  AZD0156  |  CP-466722  |  Antitumor agent-28  |  ATR-IN-12  |  ATR-IN-18  |  ATR-IN-13  |  ATR-IN-5  |  ATR-IN-20  |  ATR-IN-21  |  AZ32  |  ATM Inhibitor-2  |  ATM Inhibitor-6  |  Ro 90-7501  |  ATR-IN-17  |  A011  |  ATR-IN-4

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