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CAS No. : 2645-32-1
MCE 国际站:PR-619
产品活性:PR-619 是一种 DUB 抑制剂,作用于 USP4,USP8,USP7,USP2 和 USP5,EC50 分别为 3.93,4.9,6.86,7.2 和 8.61 μM。PR-619 可诱导内质网应激和内质网应激相关的凋亡。
研究领域:Cell Cycle/DNA Damage | Autophagy | Apoptosis
作用靶点:Deubiquitinase | Autophagy | Apoptosis
In Vitro: PR-619, a deubiquitylase inhibitor, prevents degradation, indicating KCa3.1 is targeted for degradation by ubiquitylation.
PR-619 affects the microtubule network and led to the accumulation of small punctuated tau deposits around. PR-619 causes the dephosphorylation of tau.
PR-619 (7-12.5 μM) causes an increase in the abundance of ubiquitinated proteins within 24 h. PR-619 leads to the induction of heat shock proteins and to an increase of ubiquitinated proteins.
PR-619 (9 μM) affects the organization of the microtubule network in OLN-t40 cells.
PR-619 (5, 7.5, and 10 μM) induces ER Stress and ER-Stress related apoptosis on T24 and BFTC-905 cells. PR-619 induces polyubiquitination, Bcl-2 downregulation, and concurrent PARP cleavage in a dose-dependent manner. PR-619 induces G0/G1 arrest in UC cells.
In Vivo: PR-619 (10 mg/kg/day) enhances the antitumor effect of Cisplatin on a Cisplatin-Na ve and Cisplatin-resistant UC Xenograft of nude mice.
相关产品:Bioactive Compound Library Plus | Apoptosis Compound Library | Cell Cycle/DNA Damage Compound Library | Anti-Cancer Compound Library | Autophagy Compound Library | Anti-Aging Compound Library | Ubiquitination Compound Library | Endoplasmic Reticulum Stress Compound Library | Heterocyclic Compound Library | SY-5609 | BRD4 Inhibitor-18 | SJB3-019A | 8α-Tigloyloxyhirsutinolide 13-O-acetate | USP8-IN-2 | SJB2-043 | AAPK-25 | Dutasteride-13C6 | Oleic acid-13C | Anticancer agent 120 | Abacavir sulfate | Meloxicam-d3-1 | Thailanstatin D | SB-218078 | Toyocamycin | USP7-IN-1 | Sorafenib-d4 | Busulfan | PTC-028 | USP7-IN-8 | Dinaciclib | CR-1-31-B | 142I5 | Farudodstat | Ecteinascidin 770 | AT9283 | Staurosporine | SNS-032 | AZA1 | Antitumor agent-96
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货号: HY-13814
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