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Necrostatin-1

CAS No. : 4311-88-0

MCE 国际站：Necrostatin-1

产品活性：Necrostatin-1 (Nec-1) 是一种有效的能透过血脑屏障的坏死性凋亡 (necroptosis) 抑制剂，在 Jurkat 细胞中的 EC₅₀ 为 490 nM。Necrostatin-1 抑制 RIP1 激酶 (EC₅₀=182 nM) 。Necrostatin-1 (Nec-1) 也是一种 (IDO) 抑制剂。

研究领域：Apoptosis  |  Autophagy  |  Metabolic Enzyme/Protease

作用靶点：RIP kinase  |  Autophagy  |  Indoleamine 2,3-Dioxygenase (IDO)  |  Ferroptosis

In Vitro: Necrostatin-1 (Nec-1) efficiently inhibits the TNFα-induced necrotic death of L929 cells, which does not require exogenous caspase inhibitors.
?Necrostatin-1 (Nec-1) prevents radiocontrast media (RCM)-induced dilation of peritubular capillaries, suggesting a novel role unrelated to cell death for the RIP1 kinase domain in the regulation of microvascular hemodynamics and pathophysiology of contrast-induced AKI (CIAKI).
?Necrostatin-1 (Nec-1) (30 μM) increases the survival of cardiomyocyte progenitor cell (CMPCs) by inhibiting necrotic cell death.

In Vivo: Necrostatin-1 (Nec-1) induces tubular bilation and affects the kinetics of the dilation of peritubular capillaries after RCM application. Upon a single intraperitoneal application of a single dose of Necrostatin-1 (1.65 mg/kg body weight, i.p.) 15 minutes before RCM, the return to baseline levels is prevented within the observation period.

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