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SR-3677

CAS No. : 1072959-67-1

MCE 国际站：SR-3677

产品活性：SR-3677是高效的选择性的ROCK-II抑制剂，IC₅₀值为~3 nM。

研究领域：Cell Cycle/DNA Damage  |  Stem Cell/Wnt  |  Cytoskeleton  |  TGF-beta/Smad  |  Autophagy

作用靶点：ROCK  |  Autophagy

In Vitro: SR-3677 has an IC₅₀ of ~3 nM in enzyme and cell based assays and has an off-target hit rate of 1.4% against 353 kinases, and inhibits only 3 out of 70 nonkinase enzymes and receptors. The IC₅₀ value of SR-3677 for ROCK-I is 56±12 nM. The hydrophobic interaction of the benzodioxane phenyl ring with the hydrophobic surface of the pocket is the dominating factor that contributes to the high potency of SR-3677.

In Vivo: ExVivo: Pharmacology studies shows that SR-3677 is efficacious in both, increasing ex vivoaqueous humor outflow in porcine eyes and inhibiting myosin light chain phosphorylation. Continuous exposure of 25 µM SR-3677 increases the outflow facility by 60% at 1 h perfusion, increasing to 70–80% for the 2–5 h time points.

相关产品：Bioactive Compound Library Plus  |  Cell Cycle/DNA Damage Compound Library  |  Kinase Inhibitor Library  |  Stem Cell Signaling Compound Library  |  TGF-beta/Smad Compound Library  |  Anti-Cancer Compound Library  |  Autophagy Compound Library  |  Anti-Aging Compound Library  |  Reprogramming Compound Library  |  Cytoskeleton Compound Library  |  Targeted Diversity Library  |  Anti-Pulmonary Fibrosis Compound Library  |  Cancer Stem Cells Compound Library  |  Membrane Protein-targeted Compound Library  |  Highly Selective Inhibitors Library  |  Highly Selective Activators Library  |  Chroman 1 dihydrochloride  |  Ripasudil free base  |  AS1892802  |  Hu7691 free base  |  Sovesudil  |  AT13148  |  CRT0066854  |  LX7101  |  Y-27632 dihydrochloride  |  RKI-1447  |  HA-100 hydrochloride  |  WF-536  |  Pentanoic acid-d₉  |  Fasudil dihydrochloride  |  ROCK-IN-5  |  ROCK2-IN-5  |  BDP5290  |  PF-4950834  |  PT-262  |  Afuresertib hydrochloride  |  Belumosudil mesylate  |  GSK429286A  |  Y-27632 dihydrochloride (GMP)  |  H-1152 dihydrochloride  |  3-(4-Pyridyl)indole  |  ROCK inhibitor-2  |  ROCK-IN-7  |  ZINC00881524

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