MCE 的所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务。
CAS No. : 1176316-99-6
MCE 国际站:Agomelatine hydrochloride
产品活性:Agomelatine hydrochloride (S-20098 hydrochloride) 是一种 MT1 和 MT2 受体的特异性激动剂,对 CHO-hMT1,HEK-hMT1,CHO-hMT2,HEK-hMT2 的 Ki 分别为 0.1,0.06,0.12 和 0.27 nM。Agomelatine hydrochloride 还是一种选择性的 5-HT2C 受体拮抗剂,在天然 (猪) 和克隆的人 5-HT2C 受体中 pKi 分别为 6.4 和 6.2。
研究领域:GPCR/G Protein | Neuronal Signaling | Metabolic Enzyme/Protease
作用靶点:Melatonin Receptor | 5-HT Receptor | Endogenous Metabolite
In Vitro: Agomelatine (S 20098) acts as a full agonist of MT1 and MT2 receptors with EC50s of 1.6±0.4, 0.10±0.04 nM for CHO hMT1 CHO-hMT2 (hΜΤ1 and hΜΤ2 receptors expressed in CHO or HEK cell membranes).
Agomelatine (S20098) also interacts with h5-HT2B receptors (6.6), whereas it shows low affinity at native (rat)/cloned, human 5-HT2A (<5.0/5.3) and 5-HT1A (<5.0/5.2) receptors, and negligible (<5.0) affinity for other 5-HT receptors.
In Vivo: Agomelatine (25, 50, or 75 mg/kg; i.p.) has antioxidant activity in Strychnine (75 mg/kg, i.p.) or Pilocarpine (400 mg/kg, i.p.) induced seizure models in mice. Agomelatine dose not have any antioxidant effects on parameters of oxidative stress produced by Pentylenetetrazole (PTZ) or Picrotoxin (PTX) induced seizure models when compared to controls.
相关产品:Drug Repurposing Compound Library Plus | FDA-Approved Drug Library Plus | FDA-Approved Drug Library Mini | Bioactive Compound Library Plus | GPCR/G Protein Compound Library | Metabolism/Protease Compound Library | Neuronal Signaling Compound Library | FDA-Approved Drug Library | Anti-Aging Compound Library | Drug Repurposing Compound Library | Oxygen Sensing Compound Library | Anti-COVID-19 Compound Library | Orally Active Compound Library | Neurotransmitter Receptor Compound Library | FDA Approved & Pharmacopeial Drug Library | Anti-Alzheimer's Disease Compound Library | Anti-Parkinson's Disease Compound Library | Neurodegenerative Disease-related Compound Library | Rare Diseases Drug Library | EMA-Approved Drug Library | 5-HT Receptor Compound Library | Human Metabolite Library | Coagulation and Anti-coagulation Compound Library | Membrane Protein-targeted Compound Library | Membrane Receptor-targeted Compound Library | Highly Selective Inhibitors Library | Highly Selective Activators Library | D-Valine-d8 | D-α-Hydroxyglutaric acid disodium | Nicotinamide N-oxide | SB 243213 | Perphenazine-d8 dihydrochloride | Deoxycholic acid-d5 | Doxorubicin-13C,d3 TFA | Palitantin | Estradiol hemihydrate | (Rac)-SEP-363856 | Adrenaline sulfate | Oleic acid-13C | Dextranase | H2S Donor 5a | Bromperidol-d4-1 | Methylmalonic acid | Glycine, N-(aminoiminomethyl)-N-methyl-13C | Dihydroxyacetone phosphate | Loxapine-d8 hydrochloride | Sphingomyelin | ARC 239 | (-)-Jasmonoyl-L-isoleucine | Ondansetron-d3 | Octanoic acid-d2 | Vardenafil-d5 | N-Acetyllactosamine | Zotepine | D-Arabitol-13C | Paliperidone-d4 | Imidazole
热门产品线:重组蛋白 | 化合物库 | 天然产物 | 荧光染料 | PROTAC | 同位素标记物 | 寡核苷酸 | 抗体 | 点击化学
Trending products:Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Fluorescent Dye | PROTAC | Isotope-Labeled Compounds | Oligonucleotides | Antibodies | Click Chemistry
货号: HY-17038A
品牌介绍:
• MCE (MedChemExpress) 拥有200 多种全球独家化合物库,我们致力于为全球科研客户提供前沿最全的高品质小分子活性化合物;
• 50,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领;
• 产品种类涵盖各种重组蛋白,多肽,常用试剂盒 ,更有 PROTAC、ADC 等特色产品,广泛应用于新药研发、生命科学等科研项目;
• 提供虚拟筛选,离子通道筛选,代谢组学分析检测分析,药物筛选等专业技术服务;
• 设有专业的实验中心和严格的质控、验证体系;
• 提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告,确保产品的高纯度、高品质;
• 产品的生物活性多经各国客户实验验证;
• Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果;
• 专业团队跟踪最新的制药及生命科学研究进展,为您提供全球最新的活性化合物;
• 与世界各大制药公司及知名科研机构建立了长期的合作。