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CAS No. : 1041852-85-0
MCE 国际站:AZD7507
产品活性:AZD7507 为一种有效的、可口服的 CSF-1R 抑制剂,具有抗肿瘤活性。
研究领域:Protein Tyrosine Kinase/RTK
作用靶点:c-Fms
In Vitro: AZD7507 (Compound 31) inhibits the proliferation of 3T3 cells engineered to express CSF-1R and stimulated with CSF-1 (IC50, 32 nM), shows inhibitory activity against hERG and NaV1.5, with IC50s of >30 and 26 μM.
In Vivo: AZD7507 has good rat oral PK, with in vivo clearance of 7 mL/min/kg and 42% bioavailability. In the canine L-type Ca channel assay, the IC50 is >20 μM. AZD7507 significantly decreases the number of CD68+ macrophages in mice, and also reduces the volume and mass in mice bearing CC-LP-1 and SNU-1079 cells, but not WITT-1 cells.
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货号: HY-117244
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