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Rotigotine

CAS No. : 99755-59-6

MCE 国际站：Rotigotine

产品活性：Rotigotine 是一种有效的多巴胺受体激动剂 (dopamine receptor)，其 K_i 值为 0.71 nM (dopamine D3 receptor)，4-15 nM (D2，D5，D4 receptors)，83 nM (dopamine D1 receptor)。Rotigotine 是 5-HT1A receptor 的部分激动剂和 α2B-adrenergic receptor 的拮抗剂。Rotigotine 可用于帕金森病（PD）研究。

研究领域：GPCR/G Protein  |  Neuronal Signaling

作用靶点：Dopamine Receptor  |  Adrenergic Receptor  |  5-HT Receptor

In Vitro: Rotigotine (0.01-10 µM) slightly protects dopaminergic neurons against MPP⁺ toxicity dopamine, protects dopaminergic neurons against rotenone-induced cell death and significantly inhibits ROS production by rotenone.

In Vivo: Rotigotine (0.1-5 mg/kg; i.h.; for 14 days; male Sprague–Dawley rats) has antidepressant effect.

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