MCE 的所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务。
CAS No. : 278779-30-9
MCE 国际站:GW 4064
产品活性:GW 4064 是一种有效的 FXR 激动剂,EC50 为 65 nM。
研究领域:Metabolic Enzyme/Protease | Autophagy
作用靶点:FXR | Autophagy
In Vitro: Treatment with different concentrations of GW4064 (1, 2.5, 5, 10 μM) reduces the lipid accumulation in the cells. Concordantly, GW4064 treatment significantly represses oleic acid-induced CD36 protein levels in a dose-dependent manner. Taken together, these data indicate that prevention of hepatic lipid accumulation is likely due to an inhibition of Cd36 expression by long-term GW4064 treatment.
In Vivo: GW4064 suppresses weight gain in C57BL/6 mice fed with either a high-fat diet (HFD) or high-fat, high-cholesterol diet. GW4064 treatment of mice on HFD significantly represses diet-induced hepatic steatosis as evidenced by lower triglyceride and free fatty acid level in the liver. GW4064 markedly reduces lipid transporter CD36 expression without affecting expression of genes that are directly involved in lipogenesis. GW4064 treatment attenuates hepatic inflammation while having no effect on white adipose tissue. GW4064 (30 mg/kg) treatment results in substantial, statistically significant reductions in serum activities of ALT, AST, LDH, and ALP in the ANIT-treated rats. Serum bile acid levels are also significantly reduced by GW4064 treatment. Bilirubin levels are decreased in the GW4064-treated rats, but statistical significance is not achieved. Notably, GW4064 is much more effective in decreasing these markers of liver damage than TUDCA, which reduces only LDH levels.
相关产品:Natural Product-like Compound Library | Bioactive Compound Library Plus | Metabolism/Protease Compound Library | Anti-Cancer Compound Library | Autophagy Compound Library | Nuclear Receptor Compound Library | Chenodeoxycholic acid-d5 | XJ02862-S2 | FXR antagonist 1 | Hedragonic acid | Sevelamer | Turofexorate isopropyl | EDP-305 | Ursodeoxycholic acid-13C | FXR agonist 5 | Tropifexor | INT-767 | ZLY28 | Gly-β-MCA | NDB | PX20606 trans racemate | Tauro-β-muricholic acid-d4 sodium | BAR502 | Tauro-β-muricholic acid sodium | FXR antagonist 2 | DY268 | Obeticholic acid-d5 | NR1H4 activator 1 | (Z)-Guggulsterone | Chenodeoxycholic Acid-d4 | Forskolin | Chenodeoxycholic acid-13C | Fexarine | Obeticholic Acid-d4 | Ursodeoxycholic acid | FXR/TGR5 agonist 1
热门产品线:重组蛋白 | 化合物库 | 天然产物 | 荧光染料 | PROTAC | 同位素标记物 | 寡核苷酸 | 抗体 | 点击化学
Trending products:Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Fluorescent Dye | PROTAC | Isotope-Labeled Compounds | Oligonucleotides | Antibodies | Click Chemistry
货号: HY-50108
品牌介绍:
• MCE (MedChemExpress) 拥有200 多种全球独家化合物库,我们致力于为全球科研客户提供前沿最全的高品质小分子活性化合物;
• 50,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领;
• 产品种类涵盖各种重组蛋白,多肽,常用试剂盒 ,更有 PROTAC、ADC 等特色产品,广泛应用于新药研发、生命科学等科研项目;
• 提供虚拟筛选,离子通道筛选,代谢组学分析检测分析,药物筛选等专业技术服务;
• 设有专业的实验中心和严格的质控、验证体系;
• 提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告,确保产品的高纯度、高品质;
• 产品的生物活性多经各国客户实验验证;
• Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果;
• 专业团队跟踪最新的制药及生命科学研究进展,为您提供全球最新的活性化合物;
• 与世界各大制药公司及知名科研机构建立了长期的合作。