MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

MK 0893

CAS No. : 870823-12-4

MCE 国际站：MK 0893

产品活性：MK 0893 是一种有效，选择性的胰高血糖素受体拮抗剂，IC₅₀ 值为 6.6 nM。

研究领域：GPCR/G Protein

作用靶点：GCGR

In Vitro: MK 0893 is selective for glucagon receptor relative to other family B GPCRs, showing IC₅₀ values of 1020 nM for GIPR, 9200 nM for PAC1, and >10000 nM for GLP-1R, VPAC1, and VPAC2. MK 0893 is active against the rhesus monkey GCGR, showing an IC₅₀ of 56 nM in a cAMP assay with CHO cells expressing the rhesus GCGR.

In Vivo: MK 0893 blunts glucagon-induced glucose elevation in hGCGR mice and rhesus monkeys. It also lowers ambient glucose levels in both acute and chronic mouse models: in hGCGR ob/ob mice it reduces glucose (AUC 0-6 h) by 32% and 39% at 3 and 10 mpk single doses, respectively. In hGCGR mice on a high fat diet, MK 0893 at 3, and 10 mpk po in feed lowers blood glucose levels by 89% and 94% at day 10, respectively, relative to the difference between the vehicle control and lean hGCGR mice.

相关产品：Drug Repurposing Compound Library Plus  |  Clinical Compound Library Plus  |  Bioactive Compound Library Plus  |  GPCR/G Protein Compound Library  |  Clinical Compound Library  |  Drug Repurposing Compound Library  |  Anti-diabetic Compound Library  |  Anti-COVID-19 Compound Library  |  Membrane Protein-targeted Compound Library  |  Membrane Receptor-targeted Compound Library  |  Highly Selective Inhibitors Library  |  Dulaglutide  |  PF-06291874  |  Neuropeptide Y, porcine  |  HAEGTFTSDVS  |  Glucagon receptor antagonists-5  |  Oxyntomodulin TFA  |  Tirzepatide TFA  |  Liraglutide  |  GLP-1R agonist 1  |  Exendin-4 acetate  |  GLP-1(7-37) acetate  |  Glucagon (1-29), bovine, human, porcine  |  GPCR modulator-1  |  Oxyntomodulin (swine)  |  VU0453379  |  Cotadutide  |  Elsiglutide  |  GLP-1 receptor agonist 7  |  Exendin(9-39) amide  |  Glucagon-like peptide 1 (1-37), human TFA  |  Semaglutide TFA  |  Retatrutide acetate  |  GLP-1R modulator C5  |  Glucagon (19-29), human  |  [Des-His1,Glu9]-Glucagon amide TFA  |  FC382K10W15 TFA  |  Exendin-3/4 (59-86)  |  FTSDVSKQMEEEAVRLFIEWLKNGGPSSGAPPPS

热门产品线：重组蛋白  |  化合物库  |  天然产物  |  荧光染料  |  PROTAC  |  同位素标记物  |  寡核苷酸  |  抗体  |  点击化学

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Fluorescent Dye  |  PROTAC  |  Isotope-Labeled Compounds  |  Oligonucleotides  |  Antibodies  |  Click Chemistry

货号: HY-50663

品牌介绍:
•   MCE (MedChemExpress) 拥有200 多种全球独家化合物库，我们致力于为全球科研客户提供前沿最全的高品质小分子活性化合物；
•   50,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领；
•   产品种类涵盖各种重组蛋白，多肽，常用试剂盒 ，更有 PROTAC、ADC 等特色产品，广泛应用于新药研发、生命科学等科研项目；
•   提供虚拟筛选，离子通道筛选，代谢组学分析检测分析，药物筛选等专业技术服务；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；
•   专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。