MCE 的所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务。
CAS No. : 211915-06-9
MCE 国际站:Dabigatran etexilate
产品活性:Dabigatran etexilate (BIBR 1048) 是具有口服活性的 Dabigatran (一种凝血酶抑制剂)的前体。Dabigatran etexilate具有抗凝作用,可以预防心房颤动引起的静脉血栓栓塞和中风。
研究领域:Metabolic Enzyme/Protease
作用靶点:Thrombin
In Vivo: Dabigatran etexilate (BIBR 1048; oral; 10, 20 and 50 mg/kg for rats and 1, 2.5 and 5 mg/kg for monkeys) has dose- and time-dependent anticoagulant effects and has maximum effects between 30 and 120 min after administration, respectively.
Dabigatran etexilate maximally and significantly prolongs partial thromboplastin time (aPTT) to 25.2, 38.4 and 78.3 s in 30 min after 10, 20 and 50 mg/kg oral doses, respectively.
Dabigatran etexilate maximally prolongs the aPTT to 34.3 s, 44.0 s, and 63.0 s, respectively, 2h after 1, 2.5 or 5 mg/kg doses in the monkey.
相关产品:Drug Repurposing Compound Library Plus | FDA-Approved Drug Library Plus | FDA-Approved Drug Library Mini | Bioactive Compound Library Plus | Metabolism/Protease Compound Library | FDA-Approved Drug Library | Drug Repurposing Compound Library | Anti-Cardiovascular Disease Compound Library | Anti-COVID-19 Compound Library | NMPA-Approved Drug Library | Orally Active Compound Library | FDA Approved & Pharmacopeial Drug Library | Rare Diseases Drug Library | EMA-Approved Drug Library | Human Metabolite Library | Coagulation and Anti-coagulation Compound Library | Heterocyclic Compound Library | Off-patent Drug Library | Edoxaban tosylate | Argatroban monohydrate | 15,16-Dihydrotanshindiol C | Edoxaban-d6 | Desethyl KBT-3022 | Aeruginosin 98-B | Befovacimab | Melagatran | TP508 | Inogatran | RWJ-445167 | Napsagatran hydrate | Heparin sodium salt (MW 15kDa) | Desirudin | Dabigatran-d3 | Thrombin inhibitor 6 | Metolazone-d7 | Bivalirudin | Dabigatran-d4 | Dabigatran-13C6 | Atecegatran metoxil | (1R,3S)-THCCA-Asn | TRAP-14 | Protamine sulfate | Dabigatran etexilate-d13
热门产品线:重组蛋白 | 化合物库 | 天然产物 | 荧光染料 | PROTAC | 同位素标记物 | 寡核苷酸 | 抗体 | 点击化学
Trending products:Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Fluorescent Dye | PROTAC | Isotope-Labeled Compounds | Oligonucleotides | Antibodies | Click Chemistry
货号: HY-10274
品牌介绍:
• MCE (MedChemExpress) 拥有200 多种全球独家化合物库,我们致力于为全球科研客户提供前沿最全的高品质小分子活性化合物;
• 50,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领;
• 产品种类涵盖各种重组蛋白,多肽,常用试剂盒 ,更有 PROTAC、ADC 等特色产品,广泛应用于新药研发、生命科学等科研项目;
• 提供虚拟筛选,离子通道筛选,代谢组学分析检测分析,药物筛选等专业技术服务;
• 设有专业的实验中心和严格的质控、验证体系;
• 提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告,确保产品的高纯度、高品质;
• 产品的生物活性多经各国客户实验验证;
• Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果;
• 专业团队跟踪最新的制药及生命科学研究进展,为您提供全球最新的活性化合物;
• 与世界各大制药公司及知名科研机构建立了长期的合作。