MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

Vilazodone Hydrochloride

CAS No. : 163521-08-2

MCE 国际站：Vilazodone Hydrochloride

产品活性：Vilazodone Hydrochloride (EMD 68843 Hydrochloride) 是 5-羟色胺转运体 (SER) 的抑制剂和 5-HT_1A 受体的部分激动剂。

研究领域：GPCR/G Protein  |  Neuronal Signaling

作用靶点：5-HT Receptor  |  Serotonin Transporter

In Vivo: Administration of 5-HT_1A receptor agonists produce a characteristic behavioral syndrome that includes changes in posture, hind limb reduction, head weaving, tremors, forepaw treading, and straub tail. In the rat ultrasonic vocalizations test, stress-induced vocalizations are inhibited by Vilazodone Hydrochloride (EMD 68843 Hydrochloride) (55 mg/kg po) at 120 and 210 min post dose. Vilazodone Hydrochloride (EMD 68843 Hydrochloride) (20-40 mg/kg ip), administered acutely or prophylactically (1 week prior to behavioral testing), attenuated stress induces potentiated startle but has no effect on stress potentiated anxiety response in the elevated plus maze. Interestingly, a lower dose of 10 mg/kg of Vilazodone Hydrochloride (EMD 68843 Hydrochloride) has the opposite effect in the startle response, indicating a somewhat unexplained bidirectional effect, and all doses produce a potentiation of the startle-induced stress response possibly suggestive of an anxiogenic-like response. Vilazodone Hydrochloride (EMD 68843 Hydrochloride) also represents another option for the treatment of MDD.

相关产品：Drug Repurposing Compound Library Plus  |  FDA-Approved Drug Library Plus  |  FDA-Approved Drug Library Mini  |  Bioactive Compound Library Plus  |  GPCR/G Protein Compound Library  |  Neuronal Signaling Compound Library  |  FDA-Approved Drug Library  |  Drug Repurposing Compound Library  |  Orally Active Compound Library  |  Neurotransmitter Receptor Compound Library  |  FDA Approved & Pharmacopeial Drug Library  |  Anti-Alzheimer's Disease Compound Library  |  Drug-Induced Liver Injury (DILI) Compound Library  |  Anti-Obesity Compound Library  |  Targeted Diversity Library  |  Antidepressant Compound Library  |  5-HT Receptor Compound Library  |  Human Metabolite Library  |  Coagulation and Anti-coagulation Compound Library  |  Heterocyclic Compound Library  |  Off-patent Drug Library  |  Membrane Protein-targeted Compound Library  |  Membrane Receptor-targeted Compound Library  |  Highly Selective Inhibitors Library  |  Highly Selective Activators Library  |  SB 243213  |  Perphenazine-d₈ dihydrochloride  |  (Rac)-SEP-363856  |  Bromperidol-d₄-1  |  Loxapine-d₈ hydrochloride  |  ARC 239  |  Ondansetron-d₃  |  Zotepine  |  Paliperidone-d₄  |  Dehydroaripiprazole  |  Nuciferine  |  Ziprasidone hydrochloride monohydrate  |  WAY-100635 Maleate  |  Velusetrag  |  (S)-Mirtazapine  |  Eletriptan  |  Pindolol-d₇  |  Paliperidone palmitate  |  p-MPPI hydrochloride  |  LY 344864 racemate  |  Paliperidone  |  LY-272015 hydrochloride  |  Ecopipam  |  WAY208466 dihydrochloride  |  Nelotanserin  |  PNU-96415E  |  CP-809101  |  AS19  |  Bupropion-d₉ hydrochloride

热门产品线：重组蛋白  |  化合物库  |  天然产物  |  荧光染料  |  PROTAC  |  同位素标记物  |  寡核苷酸  |  抗体  |  点击化学

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Fluorescent Dye  |  PROTAC  |  Isotope-Labeled Compounds  |  Oligonucleotides  |  Antibodies  |  Click Chemistry

货号: HY-14261

品牌介绍:
•   MCE (MedChemExpress) 拥有200 多种全球独家化合物库，我们致力于为全球科研客户提供前沿最全的高品质小分子活性化合物；
•   50,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领；
•   产品种类涵盖各种重组蛋白，多肽，常用试剂盒 ，更有 PROTAC、ADC 等特色产品，广泛应用于新药研发、生命科学等科研项目；
•   提供虚拟筛选，离子通道筛选，代谢组学分析检测分析，药物筛选等专业技术服务；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；
•   专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。