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TGX-221

CAS No. : 663619-89-4

MCE 国际站：TGX-221

产品活性：TGX-221 是一种高效的、选择性的、细胞膜渗透的 PI3K p110β 抑制剂，常用于癌症研究。

研究领域：PI3K/Akt/mTOR

作用靶点：PI3K

In Vitro: TGX-221, BL05 and BL05-HA show selective cytotoxicity to LNCaP cells, which may be due to the deficiency of PTEN in this cell line and the accumulation of PIP3 in the cells.
TGX-221 (1 μM) does not affect the expression and phosphorylation of AMPK in C2C12 myoblasts.
TGX221 (0.1, 1, 10 μM) induces IL-6 release from ASM cells.
TGX-221 does not affect neurotensin-stimulated Akt phosphorylation when used alone, but it further suppresses neurotensin-stimulated phosphorylation of Akt when combined with gefitinib. TGX-221 abolishes the neurotensin-stimulated phosphorylation of Akt in Panc-1 cells.

In Vivo: TGX-221 (TGX221, 2.5 mg/kg i.v.) abolishes cyclic flow reductions in a Folts-like carotid artery stenosis preparation of thrombosis, without changing bleeding time, heart rate, blood pressure or carotid vascular conductance.

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