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(E/Z)-Zotiraciclib

CAS No. : 937270-47-8

MCE 国际站：(E/Z)-Zotiraciclib

产品活性：(E/Z)-Zotiraciclib ((E/Z)-TG02) 是一种强效的 CDK2，JAK2 和 FLT3 的抑制剂，IC₅₀ 值分别为 13，73 和 56 nM。(E/Z)-Zotiraciclib 有效的抑制癌细胞的增殖，可用于癌症的研究。

研究领域：Cell Cycle/DNA Damage  |  JAK/STAT Signaling  |  Stem Cell/Wnt  |  Epigenetics  |  Protein Tyrosine Kinase/RTK

作用靶点：CDK  |  JAK  |  FLT3

In Vitro: (E/Z)-Zotiraciclib (0-10 μM) shows potent inhibition to CDK2, JAK2 and FLT3 with IC₅₀s of 13, 73 and 56 nM, respectively.
(E/Z)-Zotiraciclib (0-10 μM; 48 h) inhibits proliferation of cancer cells.
(E/Z)-Zotiraciclib (8-1000 nM; 24 h) potently inhibits the CDK2 biomarker pRb in HCT-116 cells and potently againsts pRb in MV4-11 cells with an IC₅₀ value of 0.13 μM.

In Vivo: (E/Z)-Zotiraciclib (50 and 75 mg/kg; p.o. once daily for 3 weeks) inhibits tumor growth.
(E/Z)-Zotiraciclib (15 and 75 mg/kg; p.o. once daily 2 days on and 5 days off; i.p. once daily 5 days on 5 days off) inhibits tumor growth in two manners.

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