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CAS No. : 24386-93-4
MCE 国际站:5-Iodotubercidin
产品活性:5-Iodotubercidin (NSC 113939),一种 ATP 类似物,是一种有效的腺苷激酶 (adenosine kinase) 抑制剂,IC50 值为 26 nM。5-Iodotubercidin (NSC 113939) 通过激活磷酸化酶和糖原合成酶,在离体肝细胞中启动糖原合成。5-Iodotubercidin (NSC 113939) 也抑制 CK1、胰岛素受体酪氨酸激酶、磷酸化酶激酶、PKA、CK2、PKC 和 Haspin 抑制剂。
研究领域:Metabolic Enzyme/Protease | Neuronal Signaling
作用靶点:Adenosine Kinase
In Vitro: 5-Iodotubercidin (NSC 113939) inhibits CK1, insulin receptor tyrosine kinase, phosphorylase kinase, PKA, CK2 and PKC, and the IC50 values are 0.4, 3.5, 5-10, 5-10, 10.9 and 27.7 μM respectively.
5-Iodotubercidin (20 μM) causes an important decrease in ATP concentration, and a concomitant smaller increase in AMP concentration. 5-Iodotubercidin decreases the activity of ACC and the rates of synthesis of fatty acids and cholesterol. In line with the iodotubercidin-mediated inhibition of ACC, 5-iodotubercidin induces a marked decrease in the intracellular concentration of malonyl-CoA.
In Vivo: 5-Iodotubercidin (1 mL/kg, i.p.) is in agreement with activity observed against bicuculline-induced seizures following local administration of the AKI into the prepiriform cortex.
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