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KN-93

CAS No. : 139298-40-1

MCE 国际站：KN-93

产品活性：KN-93是可渗透细胞，可逆和竞争性的抑制剂钙调蛋白依赖性激酶II型 (CaMKII) 抑制剂，K_i 为370 nM。

研究领域：Neuronal Signaling  |  Autophagy

作用靶点：CaMK  |  Autophagy

In Vitro: After 2 days of KN-93 treatment, 95% of cells are arrested in G1. G1 arrest is reversible; 1 day after KN-93 release, a peak of cells had progressed into S and G2-M. KN-93 also blocks cell growth stimulated by basic fibroblast growth factor, platelet-derived growth factor-BB, and epidermal growth factor in NIH 3T3 fibroblasts. KN-93 inhibits the H⁺, K⁺-ATPase activity but strongly dissipates the proton gradient formed in the gastric membrane vesicles and reduces the volume of luminal space. KN-93 (0.5 μM) prevents increased LV developed pressure during action potential prolongation and early afterdepolarizations. Ca²⁺-independent CaM kinase activity is increased during early afterdepolarizations and this increase is prevented by KN-93. KN-93 (10 μM )significantly inhibits the activation of CaMKII/NF-κB signaling induced by elevated glucose, and subsequently decreases the expression of VEGF, iNOS and ICAM-1 in Müller cells.

In Vivo: KN-93 (1 mg/kg/day, i.p.) inhibits retinal vascular leakage induced by diabetes, and suppresses phosphorylation of CaMKII and NF-κB in diabetic retina.

相关产品：Bioactive Compound Library Plus  |  Kinase Inhibitor Library  |  Neuronal Signaling Compound Library  |  Anti-Cancer Compound Library  |  Autophagy Compound Library  |  Anti-diabetic Compound Library  |  Targeted Diversity Library  |  Autocamtide-3  |  Trifluoperazine dihydrochloride  |  Calmodulin-Dependent Protein Kinase II(290-309) acetate  |  Cabamiquine  |  TX-1123  |  Autocamtide-2-related inhibitory peptide, myristoylated TFA  |  CS587  |  CaMKII-IN-1  |  TIM-063  |  KN-93 phosphate  |  KN-62  |  A-484954  |  Ph-HTBA  |  Autocamtide 2, amide  |  K-252a  |  Sordarin sodium  |  Calmidazolium chloride  |  MLCK inhibitor peptide 18  |  Syntide 2 TFA  |  Autocamtide-2-related inhibitory peptide  |  Trifluoperazine-d₃ dihydrochloride  |  Rimacalib  |  Calmodulin Dependent Protein Kinase Substrate Analog  |  PROTAC eEF2K degrader-1

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