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CAS No. : 747408-78-2
MCE 国际站:PBT 1033
产品活性:PBT 1033 (PBT 2) 是一种具有口服活性的铜/锌离子载体。PBT 1033 可恢复阿尔茨海默病 (AD) 小鼠模型中小鼠的认知能力。PB 1033 还对革兰氏阳性菌具有抗菌活性。
研究领域:Anti-infection
作用靶点:Bacterial
In Vitro: PB 1033 displays antibacterial activity against S. uberis, with a MIC value of 14.5 μM.
PBT2 (1, 3 and 7.5 μM, 6 h) protects neurons against glutamate-induced excitotoxicity.
PBT2 (10 μM, 1 or 6 h) reduces NMDAR-mediated Ca2+ flux in mouse cortical neurons.
PBT2 (0-10 μM, 1 h) increases GSK3α/β phosphorylation in SH-SY5Y cells.
PBT2 (20 μM, 1 h) prevents the formation of Zn-induced protease resistant Aβ aggregates.
In Vivo: PBT 1033 (30 mg/kg/d, p.o., 11 days) restores biochemical substrates of learning/memory in a mouse model of alzheimer's disease.
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