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CAS No. : 1613589-24-4
MCE 国际站:EIDD-2749
产品活性:EIDD-2749 (4'-Fluorouridine) 是一种口服有效的 RdRp 抑制剂。EIDD-2749 能有效抑制 RSV 和 SARS-CoV-2 的复制。EIDD-2749 还表现出抗 HCV 和淋巴细胞性脉络丛脑膜炎病毒 (LCMV) 的活性。EIDD-2749 是一种很有潜力的 COVID-19 口服研究候选剂,也适用于其他 RNA 病毒的研究。
研究领域:Anti-infection
作用靶点:RSV | SARS-CoV | HCV
In Vitro: EIDD-2749 induces a delayed stalling of phosphodiester bond formation by RSV and SARS-CoV-2 RdRP.
EIDD-2749 is rapidly anabolizes, metabolically stable, and potently antiviral in disease-relevant well-differentiated HAE cultures.
EIDD-2749 shows a ≥17-fold increase in anti-RSV potency relative to that on HEp-2 cells; however, the low cytotoxicity levels remains unchanged (CC50 169 mM), resulting in a high SI (SI = EC50/CC50) of ≥1877.
EIDD-2749 inhibits SARS-CoV-2 with an EC50 value of 0.2-0.6 M.
EIDD-2749 has an EC50 of 1.86 μM in theVero E6 cell line, cytotoxicity with a CC50 of 380 μM, and stability in human plasma.
In Vivo: EIDD-2749 (0.2, 1, 5 mg/kg; p.o.; single daily for 4 days) shows good orally efficacious in RSV infection mice model in a dose-dependent manner.
EIDD-2749 shows high efficacious to SARS-CoV-2 infection and is effective with a single daily dose versus molnupiravir administered twice daily in vivo.
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货号: HY-146246
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