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Rosabulin

CAS No. : 501948-05-6

MCE 国际站：Rosabulin

产品活性：Rosabulin (STA 5312) 是一种有效的具有口服活性的微管 (microtubule) 抑制剂，可抑制微管组装。Rosabulin 具有广谱抗肿瘤活性。

研究领域：Cell Cycle/DNA Damage  |  Cytoskeleton

作用靶点：Microtubule/Tubulin

In Vitro: Rosabulin (STA 5312) demonstrates substantial anti-proliferative activity against a wide range of cancer cell linesin vitro, including hematologic and solid tumor cell lines of various origins (e.g. leukemia, lymphoma, breast, colon, uterine), with IC₅₀ values extending down into the nanomolar range. Cell lines with multi-drug resistant (MDR) phenotypes are similarly sensitive to Rosabulin. The mechanism of action for Rosabulin is inhibition of microtubule assembly and subsequent arrest of the cell cycle.

In Vivo: When dosed orally or intravenously, Rosabulin (STA 5312) has shown in vivo activity in several murine tumors as well as human tumor xenograft models, including drug resistant tumors.

相关产品：Clinical Compound Library Plus  |  Bioactive Compound Library Plus  |  Cell Cycle/DNA Damage Compound Library  |  Anti-Cancer Compound Library  |  Clinical Compound Library  |  Anti-Aging Compound Library  |  Cytoskeleton Compound Library  |  Orally Active Compound Library  |  Anti-Lung Cancer Compound Library  |  Anti-Blood Cancer Compound Library  |  Protein-protein Interaction Inhibitor Library  |  Heterocyclic Compound Library  |  Tirbanibulin dihydrochloride  |  Tubulysin IM-3  |  AMXI-5001 hydrochloride  |  Tubulin polymerization-IN-21  |  Dolastatin 10  |  SB-216  |  MAP4343  |  Tubulin polymerization-IN-8  |  Tubulysin IM-1  |  Colchicine-d₃  |  2-Methoxyestradiol-¹³C,d₃  |  Taltobulin  |  Albendazole  |  Tilavonemab  |  DM4-d₆  |  EGFR-IN-57  |  Epothilone B  |  Epothilone A  |  Maytansinol  |  Docetaxel-d₉  |  Verubulin hydrochloride  |  VcMMAE  |  Tubulin polymerization-IN-15  |  Combretastatin A-1  |  Tubulin/HDAC-IN-1  |  Mc-MMAE  |  7-epi-Taxol  |  Thiocolchicine  |  Fosbretabulin disodium  |  PEG4-aminooxy-MMAF

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