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CAS No. : 1146618-41-8
MCE 国际站:SNS-314 mesylate
产品活性:SNS-314 mesylate 是一种有效的选择性极光激酶 (aurora) 抑制剂,对极光激酶 A,B,C 的IC50 值分别为 9,31 和 6 nM。
研究领域:Cell Cycle/DNA Damage | Epigenetics
作用靶点:Aurora Kinase
In Vitro: SNS-314 blocks proliferation in a broad panel of tumor cell lines (HCT116, A2780, PC-3, HeLa, MDA-MB-231, H-1299, and HT29) with IC50 values ranging from 1.8 nM in A2780 ovarian cancer cells to 24 nM in HT29 colon cancer cells.
In Vivo: In the HCT116 human colon cancer xenograft model, administration of 50 and 100 mg/kg SNS-314 leads to dose-dependent inhibition of histone H3 phosphorylation for at least 10 h. SNS-314 shows significant tumor growth inhibition in a dose dependent manner under a variety of dosing schedules including weekly, bi-weekly, and 5 days on/9 days off.
相关产品:Covalent Screening Library Plus | Clinical Compound Library Plus | Bioactive Compound Library Plus | Cell Cycle/DNA Damage Compound Library | Epigenetics Compound Library | Kinase Inhibitor Library | Anti-Cancer Compound Library | Clinical Compound Library | Autophagy Compound Library | Anti-Aging Compound Library | Covalent Screening Library | Cytoskeleton Compound Library | Anti-Blood Cancer Compound Library | Heterocyclic Compound Library | Membrane Protein-targeted Compound Library | Highly Selective Inhibitors Library | AAPK-25 | AT9283 | Aurora kinase inhibitor-3 | Aurora Kinases-IN-2 | ENMD-2076 Tartrate | Barasertib-HQPA | dAURK-4 | AMG 900 | SCH-1473759 | Aurora A inhibitor 1 | BI-847325 | CCT129202 | Tripolin A | ZM-447439 | LY3295668 | TAK-632 | Aurora inhibitor 1 | MK-8745 | Ilorasertib | JB170 | PHA-680632 | Aurora kinase inhibitor-8 | SNS-314 | Hesperadin | Tozasertib | Alisertib | Aurora A/PKC-IN-1 | Derrone | KW-2449
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Trending products:Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Fluorescent Dye | PROTAC | Isotope-Labeled Compounds | Oligonucleotides | Antibodies | Click Chemistry
货号: HY-12003
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