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IMM-H007

CAS No. : 1221412-23-2

MCE 国际站：IMM-H007

产品活性：IMM-H007 (WS070117) 是一种口服有效的 AMPK (AMP 活化蛋白激酶) 激活剂和 TGFβ1 (转化生长因子 β1) 拮抗剂。 IMM-H007 通过激活 AMPK (AMP 活化蛋白激酶)对心血管疾病具有保护作用。 IMM-H007 通过失活 NF-κB 和 JNK/AP1 信号通路负向调节内皮细胞炎症反应。IMM-H007 抑制 ABCA1 的降解。 IMM-H007 通过调节脂质代谢来解决高脂饮食喂养的仓鼠的肝脏脂肪变性。IMM-H007 可用于非酒精性脂肪肝 (NAFLD) 和炎性动脉粥样硬化的研究。

研究领域：PI3K/Akt/mTOR  |  Epigenetics  |  TGF-beta/Smad  |  NF-κB  |  MAPK/ERK Pathway  |  Immunology/Inflammation

作用靶点：AMPK  |  TGF-β Receptor  |  NF-κB  |  JNK  |  AP-1

In Vivo: IMM-H007 inhibits fatty acid import into hepatocytes and liver lipogenesis, and concomitantly stimulates fatty acid oxidation, autophagy, and export of hepatic lipids.
IMM-H007 (200 mg/kg, Orally, once per day for 10 days) inhibits ISO-induced cardiac fibrosis and diastolic dysfunction independently of AMPKα2 expression, reduces ISO-induced Smad2/3 phosphorylation downstream of TGFβ1 and cardiac fibrosis via an AMPKα2-independent pathway, but the inhibition of TGFβ1 expression is AMPKα2-dependent.

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