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CAS No. : 1152197-23-3
MCE 国际站:8-pCPT-2'-O-Me-cAMP-AM
产品活性:8-pCPT-2'-O-Me-cAMP-AM 是一类循环的 AMP 类似物,能够选择性激活 Epac-Rap 信号通路。8-pCPT-2'-O-Me-cAMP-AM 通过激活 Epack 可保护缺血损伤下的肾功能。8-pCPT-2'-O-Me-cAMP-AM 也通过与 PKA 通路相互作用刺激胰岛素分泌。
研究领域:Stem Cell/Wnt
作用靶点:PKA
In Vitro: 8-pCPT-2'-O-Me-cAMP-AM (2.5 μM; 30 min) activates Epac and prevents adherens junction disassembly during hypoxia (60 min).
8-pCPT-2'-O-Me-cAMP-AM can cross the plasma membrane and is able to alter diverse cellular functions that include Rap1 GTPase activity, PKB, and ERK1/2 protein kinase activity, phospholipase C activity, Ca2+ signaling, ion channel activity, exocytosis, cell adhesion, and gene expression.
8-pCPT-2'-O-Me-cAMP-AM stimulates insulin secretion with dose-dependent and glucose metabolism-dependent (0.1 or 1.11 mM) actions.
8-pCPT-2'-O-Me-cAMP-AM (20 μM) activates the cAMP reporter Epac1-camps, while 8-pCPT-2'-O-Me-cAMP doesn’t in INS-1 cells.
8-pCPT-2'-O-Me-cAMP-AM (0.3-3.0 μM; 0-300 sec) activates Epac1-camps in a dose- and time-dependent manner in high throughput assay.
In Vivo: 8-pCPT-2'-O-Me-cAMP-AM (intrarenal injection; ) activates renal Rap1 and likely is caused by activation of Epac in the tubular epithelium.
8-pCPT-2'-O-Me-cAMP-AM preserves renal function by Epac activation and reduces tubular epithelial-cell stress during ischemia.
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