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MCE 国际站:JAK-IN-23
产品活性:JAK-IN-23 是 JAK/STAT 和 NF-κB 的双重抑制剂,具有口服活性。JAK-IN-23 对J AK1/2/3 具有抑制作用,IC50 值分别为 8.9 nM、15 nM 和 46.2 nM。JAK-IN-23 对干扰素刺激基因 (ISG) 和 NF-κB 通路具有较强的抑制活性,IC50 值分别为 3.3 nM 和 150.7 nM。JAK-IN-23 具有很强的抗炎作用,可以减少各种促炎因子的释放。JAK-IN-23 可用于炎症性肠病 (IBD) 的研究。
研究领域:Epigenetics | Protein Tyrosine Kinase/RTK | JAK/STAT Signaling | Stem Cell/Wnt | Immunology/Inflammation | NF-κB
作用靶点:JAK | STING | NF-κB | STAT
In Vitro: JAK-IN-23 inhibits JAK1/2/3 with IC50 values of 8.9 nM, 15 nM and 46.2 nM, respectively.
JAK-IN-23 shows potent inhibitory activities against ISG and NF-KB with IC50 values of 3.3 nM and 150.7 nM, respectively.
WB--- JAK-IN-23 (0.33μM, 1μM, 3μM; 24 h) can simultaneously block JAK-STAT1/3 and NF-κB proinflammatory signaling pathways in THP1-dual cells.
JAK-IN-23 (0.003-3 μM; 24 h) decreases the release of various proinflammatory factors, including IL-6, IL-8, IL-1β in THP1-dual cells stimulated by LPS.
JAK-IN-23 (0.11-3 μM; 24 h) decreases the release of various proinflammatory factors, including TNF-α, IL-12, IL-10 and IFNγ in LPS-induced peripheral blood mononuclear cells (PBMCs).
JAK-IN-23 (1 μM) inhibits the expression of a variety of inflammation-related genes induced by LPS, including IL-1B, TNF, IL12B, and IL-23A and has inhibitory effects on the expression of genes involved in the unfolded protein response that was induced by LPS (1 μg/mL).
In Vivo: JAK-IN-23 (1-5 mg/kg, oral) produces a strong anti-inflammatory activity in both dextran sulfate sodium (DSS) - and 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced acute enteritis models and restores the structural composition of gut microbiota.
相关产品:Bioactive Compound Library Plus | Epigenetics Compound Library | Immunology/Inflammation Compound Library | JAK/STAT Compound Library | Kinase Inhibitor Library | NF-κB Signaling Compound Library | Protein Tyrosine Kinase Compound Library | Stem Cell Signaling Compound Library | Small Molecule Immuno-Oncology Compound Library | Anti-Aging Compound Library | Antioxidant Compound Library | Differentiation Inducing Compound Library | Reprogramming Compound Library | Oxygen Sensing Compound Library | Pyroptosis Compound Library | Orally Active Compound Library | Anti-Breast Cancer Compound Library | Anti-Lung Cancer Compound Library | Anti-Pancreatic Cancer Compound Library | Anti-Blood Cancer Compound Library | Anti-Cancer Metabolism Compound Library | Anti-Obesity Compound Library | Transcription Factor-Targeted Library | Anti-Liver Cancer Compound Library | Antidepressant Compound Library | Anti-Prostate Cancer Compound Library | Cancer Stem Cells Compound Library | Pain-Related Compound Library | Highly Selective Inhibitors Library | 8α-Tigloyloxyhirsutinolide 13-O-acetate | JAK-IN-20 | Stafia-1-dipivaloyloxymethyl ester | IMD-ferulic | Karacoline | 5-Hydroxy tryptophol β-D-glucuronide-d4 | JAK1-IN-9 | AT9283 | RO495 | TK4b | Mangiferin | JAK-IN-17 | (E/Z)-Zotiraciclib | Dauricine | (rac)-AG-205 | JAK-IN-10 | Cyclic-di-GMP disodium | Poricoic acid A | Dazostinag disodium | Ginsenoside Rg1 | GS143 | Niclosamide monohydrate | QNZ | 5-Aminosalicylic Acid-d3 hydrochloride | Lucyoside B | (3R,4S)-Tofacitinib | JAK3/BTK-IN-6 | Sulindac | Colistin adjuvant-1 | STING-IN-2
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Trending products:Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Fluorescent Dye | PROTAC | Isotope-Labeled Compounds | Oligonucleotides | Antibodies | Click Chemistry
货号: HY-151262
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