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CAS No. : 588674-64-0
MCE 国际站:CCR6 antagonist 1
产品活性:CCR6 antagonist 1 是一种 CCR6 拮抗剂,可抑制 CCL20/CCR6 信号通路。 CCR6 antagonist 1 可用于自身免疫介导的炎症性疾病的研究,如炎症性肠病 (IBDs)。
研究领域:GPCR/G Protein | Immunology/Inflammation
作用靶点:CCR
In Vitro: CCR6 antagonist 1 (compound 1b, 50 μM, 3 h) blocks the CCL20-induced CD4+ T cell migration.
?CCR6 antagonist 1 (30 nM-300 μM, 20 min) inhibits miniGi recruitment to CCR6 induced by CCL20, and β-arrestin-1 recruitment to CCR6 and CCR5 by CCL20 and CCL5 (5 nM), respectively.
In Vivo: CCR6 antagonist 1 (compound 1b, 1 mg/kg, s.c., twice daily for 3 days) alleviates TNBS-induced inflammatory responses in mice.
?CCR6 antagonist 1 (1 mg/kg, s.c., twice, before and after zymosan treatment) shows anti-inflammatory effects
in Zymosan-induced peritonitis mice.
相关产品:Bioactive Compound Library Plus | GPCR/G Protein Compound Library | Immunology/Inflammation Compound Library | Small Molecule Immuno-Oncology Compound Library | Anti-Pulmonary Fibrosis Compound Library | Chemokine Compound Library | Heterocyclic Compound Library | Membrane Protein-targeted Compound Library | Membrane Receptor-targeted Compound Library | DAPTA | BMS-753426 | BMS-813160 | JNJ-27141491 | CCR5 antagonist 2 | AZD-5672 | CCR5 antagonist 3 | Vercirnon | GSK2239633A | Bindarit | Leronlimab | Maraviroc | Plozalizumab | AZD-1678 | CCR4 antagonist 3-1 | Aplaviroc hydrochloride | CCR1 antagonist 6 | J-113863 | CCR1 antagonist 11 hydrochloride | AZD2423 | AZD2098 | RS102895 hydrochloride | LMD-009 | Carlumab | Vicriviroc maleate | CKLF1-C19 | ALK4290 | CCR1 antagonist 10 | ZK756326 dihydrochloride | INCB 3284 dimesylate
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